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ARTICLE | Emerging Company Profile

Adenium: Lugworms vs. superbugs

Adenium peptides kill resistant Gram-negative pathogens by novel MOA

October 21, 2013 7:00 AM UTC

Adenium Biotech ApS is developing derivatives of arenicin-3 to create a safer antibiotic than colistin to treat infections caused by multidrug-resistant Gram-negative pathogens.

Colistin is a broad-spectrum Gram-negative antibacterial first introduced in 1952. It was replaced by safer antibacterials in the 1970s due to its nephrotoxicity and neurotoxicity, yet it saw a resurgence in the late 1990s as the last line of defense against multidrug-resistant Gram-negative pathogens...