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Apr 29, 2013
 |  BioCentury  |  Emerging Company Profile

TissUse: Human on a chip

TissUse's multi-organ array could supplement, replace animal, human testing

TissUse GmbH is developing a system to allow for long-term maintenance of multiple human tissues or organoids on an array. This "human-on-a-chip" could eventually supplement or replace some preclinical and clinical safety testing. TissUse's long-term plan is to generate a disease model that might also provide early efficacy data.

The platform is smartphone-sized and self-contained. A peristaltic pump on the chip operates a microcirculation system interconnecting several tissue culture spaces within a polydimethylsiloxane (PDMS)-embedded microfluidic channel system. The chip emulates the fluid dynamics and fluid-to-tissue ratios of human biology.

TissUse's first multi-organ chip, which the company expects to launch in 2015, consists of two miniature organs - liver and skin - that are 100,000 times smaller than their full-scale counterparts. According to the company, human miniaturized 3-D liver organoids and human foreskin biopsies have been functionally maintained in the system over 28 days.

The company said the liver is the "number one priority organ for pharma" because it is the prime metabolic organ for drugs. According to TissUse, the two organs together can show whether metabolites of...

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