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ARTICLE | Emerging Company Profile

Cleave: Proteasome alternatives

Cleave unveils targets for its protein homeostasis inhibitors for cancer

March 25, 2013 7:00 AM UTC

Cleave Biosciences Inc. is developing small molecules against new targets that regulate protein homeostasis. The compounds could offer better bioavailability than existing proteasome inhibitors and work in a wider range of cancers, including solid tumors.

The company is banking on assays and chemical matter in-licensed from scientific co-founders including Raymond Deshaies, a California Institute of Technology professor of biology and Howard Hughes Medical Institute investigator who co-founded proteasome inhibitor cancer company Proteolix Inc...