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12:00 AM
Feb 04, 2013
 |  BioCentury  |  Emerging Company Profile

Kite: Immune system rewrite

Kite reprogramming T cells with technology from NCI for cancer immunotherapy

Kite Pharma Inc. thinks its autologous T cell technology can address multiple malignancies regardless of the underlying mechanism or biology. It says the platform has shown durable efficacy following a single dose in trials at the National Cancer Institute.

Kite was founded in 2009 to develop cancer immunotherapies and in 2011 licensed DC-AdGM-CAIX from the University of California, Los Angeles. The therapy comprises dendritic cells engineered to express a fusion protein of carbonic anhydrase IX (CAIX) and granulocyte macrophage colony-stimulating factor (GM-CSF; CSF2).

The product is in a Phase I trial in patients with clear cell renal cell carcinoma (RCC).

Last October, Kite signed a Cooperative Research and Development Agreement (CRADA) with NCI in which the biotech received access to an autologous T cell technology to treat hematological and solid cancers.

According to Kite President and CEO Aya Jakobovits, the CRADA covers the development of current...

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