12:00 AM
Jul 02, 2012
 |  BioCentury  |  Emerging Company Profile

Activiomics: Unlabeled proteomics

Activiomics' proteomics platform quantifies significant changes in human tissue

Most proteomics platforms that rely on labeling can only be used in cell lines and handle a small number of samples in any one experiment, making it difficult to quantify significant changes in cell signaling. In contrast, Activiomics Ltd.'s TIQUAS label-free proteomics software can be used in human tissue samples and can quantify statistically significant changes in kinase phosphorylation.

The result, according to the company, is more robust conclusions in biomarker discovery.

Activiomics is focused on components of kinases, called phosphopeptides, that are up- and down-regulated in kinase signaling. Kinases are integral to cell signaling in cancer, inflammation and metabolic diseases.

Most proteomics technologies - such as stable isotope labeling by amino acids in cell culture (SILAC) - use a chemical or metabolic label to tag proteins. This allows the proteins, and changes to the proteins, to be quantified.

But according to Activomics, labeled proteomics...

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