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12:00 AM
Sep 13, 2010
 |  BioCentury  |  Emerging Company Profile

Eureka: Finding foreign signatures

Eureka aims to identify new links between microorganisms, disease

Eureka Genomics Corp. is using its ability to detect and identify DNA from an unknown source to discover associations between microorganisms and disease. The ultimate goal is to develop molecular diagnostics that detect microorganisms associated with chronic diseases like cancer, cardiovascular and neurological disorders. Much as discovery of the link between HPV and cervical cancer revolutionized the treatment paradigm for that disease, Eureka hopes its work will enable earlier detection and intervention, and ultimately new vaccines and treatments.

Most sequence analysis tools for identifying non-host DNA require a researcher to hypothesize which pathogen or microorganism could be associated with disease. The known DNA sequences of those organisms are then compared with DNA sequences from human tissue or blood samples.

However, these methods are limited by the amount of available sequence data and the ability of algorithms to identify complex stretches of foreign DNA that are different from the host DNA, according to CSO and co-founder Heather Koshinsky. Because of these limitations, detecting new associations between disease and a...

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