12:00 AM
Sep 24, 2007
 |  BioCentury  |  Emerging Company Profile

Molecular Partners: Repeats by design

Molecular Partners AG believes the small size, high stability and specificity of its Designed Ankyrin Repeat Proteins can address targets and indications that have yet to be touched by classic monoclonal antibodies, where issues of size, stability and manufacturing capacity can limit their utility.

The company's DARPins are engineered antibody-like molecules that consist of repeat proteins, which themselves are composed of a structural unit of amino acids that is repeated any number of times.

These repeating units, also known as repeat modules, are stacked together to form repeat domains. Such structures are found in most organisms but are predominant in jawless vertebrates, where their function is analogous to that of antibodies in humans.

Repeat proteins also are found in humans. For instance, some endogenous kinase inhibitors are based on repeat proteins. Another example are ribonuclease inhibitors, which are endogenous leucine-rich repeat proteins.


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