12:00 AM
 | 
Mar 08, 2004
 |  BioCentury  |  Emerging Company Profile

Trophos: Cell snapshot

Technology allowing large-scale, real time observation of alterations in cell physiology remains a holy grail for researchers because it will allow more efficient discovery and optimization of new therapeutics. Trophos S.A. has taken a step in this direction with its flash cytometry technology, a fluorescent plate imaging technique that takes snapshots of live neurons in culture. The company is using the technology to discover and develop neuroprotective small molecules.

To identify its compounds, Trophos has developed in vitro assays using isolated neurons in conditions designed to mimic clinical pathologies. "We set up the cultures in conditions where the neurons die," said CSO Rebecca Pruss. "Then we add trophic factors and monitor to see if the cells are alive or dead. Then we add small drug-like molecules to see if they increase survival or not."

Although working with live...

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