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12:00 AM
 | 
Jul 28, 2003
 |  BioCentury  |  Emerging Company Profile

Nuevolution: HTS in a tube

The ultimate high throughput screen (HTS) would run every possible molecule against a given target in one test tube and identify multiple structurally unique leads. This is what Nuevolution A/S hopes to offer with its Chemetics technology, which tries to eliminate traditional limitations of HTS, including limited library size, time-consuming screening, and a narrow set of leads characterized by high structural similarity. Chemetics mixes the building blocks of small molecules together in one tube and uses DNA as a molecule generator. The result is a large and highly diverse library in a single iteration within one test tube.

One of the main drawbacks of traditional wet HTS lies in the required logistics, such as compound storage and capital expense for the necessary machinery, as well as the time- and therefore cost-consuming process of setting up assays in HTS format in an ultra-pure fashion. Also, Nuevolution CEO Zahed Subhan noted that existing ultra-high throughput systems set high demands on the purity of library compounds, which limits scalability.

In addition,...

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