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12:00 AM
May 05, 2003
 |  BioCentury  |  Emerging Company Profile

BioSeek: Human cell systems

Ideally, model systems would accurately reflect the complexity of the human body in its entirety. Companies are approaching this objective from a variety of angles: some are purely computational and others use model organisms. BioSeek Inc. is taking a direct approach by developing systems using primary cells obtained from the human body.

"The best model for the human cell is the human cell" said BioSeek President Rolf Ehrhardt. "It's not a worm. It's not a fly. It's not a rat."

But the problem with currently available human cell lines, according to Ehrhardt, is they are engineered tumor cells that don't reflect the natural and complex regulatory activity inherent in humans. Thus BioSeek works with primary cells directly isolated from human bodies. In these cells, multiple regulatory pathways remain intact, reflecting human pathophysiology.

For BioSeek, the main technological hurdle...

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