12:00 AM
Aug 27, 2001
 |  BioCentury  |  Emerging Company Profile

Personal Chemistry: Power to the Chemists

Lead optimization and medicinal chemistry are surprisingly slow and painstaking processes. The work most often is guided by the creativity of individual chemists aided by limited informatics, databases and the available literature. Attempts to industrialize the process simply by creating and screening large numbers of molecules have been disappointing. Personal Chemistry AB has introduced instruments and methodology that it believes can help chemists by decreasing the time it takes to do chemical reactions while increasing the yield.

"We see chemistry as one of the bottlenecks in drug development, especially in lead optimization and medicinal chemistry," said CEO Hans Johansson. "Medicinal chemistry has not been developed into a high or medium throughput science the way most other parts of the drug discovery process have. Thus there is a need for a paradigm shift to generate an increased output per chemist."

Combinatorial chemistry didn't solve the problem. "When looking at the development of chemistry in the early to mid 90s, there was a lot of automation and the...

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