Isis Pharmaceuticals other research news

ISIP researchers reported in the Journal of Biological Chemistry that addition of methoxyethyl to the 2' hydroxyl groups of an antisense oligonucleotide targeting ICAM-1 (cell adhesion molecule) efficiently inhibited ICAM-1 protein production.

Treatment of human cultured endothelial cells with 6 nM of ISIS 11158 allowed 25 percent of ICAM-1 protein to be made compared to controls, while 50 nM of compound resulted in no protein expression. The technology is being developed as part of ISIP's antisense collaboration with Novartis (Basel, Switzerland). ...