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Apollon, University of Pennsylvania other research news
July 21, 1997 7:00 AM UTC
Apollon and university researchers published in Nature Biotechnology the use of CD86 coexpression, along with plasmid DNA encoding for HIV-1 antigens, to stimulate cytotoxic T lymphocyte (CTL) induction. The technique could help optimize immune responses generated by DNA vaccination.
Normal mice were immunized by intramuscular injection of 50 µg of plasmid DNAs encoding HIV-1 gag/pol proteins or env protein either alone or in combination with plasmids encoding CD86 antigen presentation proteins. ...