Philadelphia groups partner to target Tregs for lung cancer

AUM LifeTech Inc. (Philadelphia, Pa.), Children's Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania partnered to develop an RNA silencing immunotherapy to treat lung cancer.

The therapeutic, which comprises fluoroarabinonucleic acid (FANA) antisense oligonucleotides (ASOs), targets the immunosuppressive master regulatory transcription factor Forkhead box P3 (FOXP3) on Tregs...