Canji Inc. deal

The San Diego company acquired a patented delivery system for gene therapies from American Gene Therapy Inc. (Edmonton, Alberta). Based on the human centromere, a structure composed of DNA that holds chromosomes together, the mammalian artificial minichromosome (MAC) technology is designed to insert a complete artificial chromosome into the nucleus of cells.

Because the genes would sit in the nucleus and not be inserted into the target cell's genome, the transferred genes could be expressed without interfering with or disrupting the host cell's genome. In addition, a large number of gene sequences and their control sequences, as well as selection markers, could be transferred. ...