12:00 AM
Mar 10, 2014
 |  BC Week In Review  |  Clinical News  |  Preclinical Results

Synta preclinical data

In mouse xenograft tumor models, STA-12-8666 safely delivered >10 times greater levels of SN-38, the active metabolite of irinotecan, vs. the maximum tolerated dose (MTD) of unconjugated irinotecan. Compared to the MTD of 50 mg/kg unconjugated irinotecan, STA-12-8666 significantly reduced tumor volume at a...

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