ARTICLE | Clinical News
Alnylam preclinical data
December 17, 2012 8:00 AM UTC
In a mouse model of AAT deficiency, single doses of IV ALN-AAT led to 90% knockdown of liver AAT mRNA and a >80% reduction in serum AAT at 48 hours post-treatment. Additionally, 0.3 mg/kg ALN-AAT give...