Trevena preclinical data

In a canine model of heart failure, furosemide plus TRV027 led to significant reductions in mean arterial pressure, systemic and pulmonary vascular resistances, pulmonary capillary wedge pressure and natriuretic peptide precursor A ( NPPA; ANP) levels vs. furosemide plus placebo (p<0.05 for all). Additionally, increases in furosemide-mediated diuresis and natriuresis were similar between the TRV027 and placebo groups. Data were published in Circulation: Heart Failure. ...