Astex Pharmaceuticals, Cancer Research Technology preclinical data

In mouse models of solid tumors, AT13148 slowed tumor growth in EGFR2 ( HER2; ErbB2; neu)-positive breast cancer and phosphoinositide 3-kinase (PI3K) alpha mutation BT474-expressing breast cancer, as well as in phosphatase and tensin homolog deleted on chromosome ten ( PTEN; MMAC1; TEP1)-deficient prostate cancer. Data were published in Clinical Cancer Research. ...