AVI BioPharma preclinical data

In ferrets infected with pandemic H1N1 influenza virus, intraperitoneal 10 mg/kg AVI-7100 reduced combined daily average viral titer through peak viral load (days 1-3) by up to 3.9 log10 copies/mL, which was significant vs. each saline- and Tamiflu oseltamivir-treated controls (p=0.0012 and p=0.0103, respectively). Furthermore, the number of infiltrating macrophages in the bronchiolar space was reduced in AVI-7100-treated ferrets compared to controls. ...