Apollon preclinical data

Apollon announced that chimpanzees vaccinated with its product were protected from HIV infection. As reported in Nature Medicine, the two chimps received several doses of the vaccine. Both antibody and killer T cell responses were stimulated against HIV. Both animals were free of virus at 22 weeks after challenge with enough virus to infect 250 chimpanzees. Biopsied lymph nodes were examined with PCR to detect virus. Blood taken nearly a year after challenge also was free of virus, as tested by reverse transcriptase PCR.

Bupivacaine, a local anesthetic, was included in the vaccine formulation as a facilitating agent to enhance both the uptake of DNA and gene expression. ...