Biogen updates Phase III AD studies

EVP and CMO Alfred Sandrock from Biogen Inc. (NASDAQ:BIIB) said the company will enroll a total of an additional 510 patients in the Phase III ENGAGE and EMERGE trials of aducanumab (BIIB037) to treat early Alzheimer's disease. The candidate is a human recombinant anti-beta amyloid mAb.

Sandrock said at the Leerink Partners Global Healthcare Conference that in a pre-planned blinded sample size re-estimation, the company found "variability" in the primary endpoint of Clinical Dementia Rating-Sum of Boxes (CDR-SB) score at week 78 and decided to increase enrollment to maintain 90% power. Biogen still plans to complete enrollment by mid-year...