1:42 PM
 | 
Dec 01, 2017
 |  BC Week In Review  |  Clinical News  |  Clinical Status

Regeneron to discontinue nesvacumab/Eylea combo

Regeneron Pharmaceuticals Inc. (NASDAQ:REGN) said it will discontinue development of a fixed combination therapy comprising nesvacumab (REGN910) plus Eylea aflibercept to treat diabetic macular edema (DME) and wet age-related macular degeneration (AMD) after the combination "did not provide sufficient differentiation" from Eylea monotherapy in two Phase II trials.

The Phase II RUBY and ONYX trials compared nesvacumab plus Eylea, formulated as a single intravitreal injection, to Eylea alone in...

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