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ARTICLE | Clinical News

Arrowhead's third-generation RNAi shows initial efficacy against HBV

September 14, 2018 3:19 PM UTC

Arrowhead Pharmaceuticals Inc. (NASDAQ:ARWR) reported initial data showing that monthly doses of its third-generation RNAi therapy ARO-HBV reduced circulating hepatitis B surface antigen (HBsAg) levels in a broad population of patients with chronic HBV infection.

The data were from eight patients that received three monthly subcutaneous doses of ARO-HBV in the lowest two dose cohorts of the Phase I/II AROHBV1001 trial. The cohorts included both hepatitis B e antigen (HBeAg)-positive patients and harder to treat HBeAg-negative patients, irrespective of prior treatment with nucleoside/nucleotide viral replication inhibitors (NUCs)...

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Arrowhead Pharmaceuticals Inc.