Sanofi (Euronext:SAN; NYSE:SNY) and Regeneron Pharmaceuticals Inc. (NASDAQ:REGN) reported data from the 18,924-patient Phase III ODYSSEY OUTCOMES trial showing that Praluent alirocumab given on top of statins lowered the risk of major adverse cardiovascular events (MACE) by 15% (HR=0.85, CI: 0.78, 0.93, p=0.0003). The MACE composite endpoint includes patients who experienced a heart attack, stroke, death from coronary heart disease (CHD) or unstable angina requiring hospitalization. Data were presented at the American College of Cardiology meeting in Orlando.
Armed with the cardiovascular outcomes data and a fresh cost-effectiveness analysis from the Institute for Clinical and Economic Review (ICER), the partners also proposed to reduce barriers to access in high-risk patients, offering up to a 69% discount to the PCSK9 inhibitor’s list price...
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