Researchers at the University of Birmingham (Birmingham, U.K.) reported data from a Phase I trial in 9 healthy volunteers showing that escalating doses of leukemia candidate pDOM-HA-1 boosted with a modified vaccinia Ankara virus (MVA) were safe with no serious adverse events reported.
pDOM-HA-1 is vaccine against histocompatibility minor HA-1 (HMHA1; HA-1; HLA-HA1). The candidate is being developed as a pretreatment for lymphocyte donors before allogeneic stem cell transplant to treat leukemia. Vaccination of HA-1-negative donors before they donate could generate cytotoxic T lymphocyte (CTLs) that recognize HA-1 in patients whose leukemias express that antigen...
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