Achaogen reports Phase I data for antibacterial candidate C-Scape
Achaogen Inc. (NASDAQ:AKAO) reported top-line data from a Phase I in 41 healthy volunteers with and without renal impairment showing that antibacterial candidate C-Scape for 14 days was well tolerated with no serious adverse events reported. The most common adverse events reported included vascular access-site bruising, headache, diarrhea, gastroenteritis and nausea. The company is developing the oral combination of ceftibuten, a third-generation cephalosporin, and clavulanate, a beta lactamase (LACTB) inhibitor, to treat multi-drug resistant (MDR) gram-negative bacterial infections. The double-blind, placebo-controlled, Australian trial evaluated the safety and pharmacokinetics of C-Scape.
This year, Achaogen plans to start a Phase III trial of the product to treat complicated urinary tract infections (cUTIs)...
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