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Jun 02, 2014
 |  BC Week In Review  |  Clinical News  |  Clinical Results

Cabozantinib: Phase II data

A single-arm, open-label, U.S. Phase II trial in 37 patients with EGFR mutation-positive NSCLC that progressed following an EGFR tyrosine kinase inhibitor (TKI) therapy showed that once-daily 40 mg oral cabozantinib plus Tarceva erlotinib led to 4 partial responses. Additionally, 20 of 23 evaluable patients had a >=30% increase in tumor doubling time. The most common grade 3 adverse event was diarrhea and 2 patients had grade 3 maculopapular rash. Grade 4 adverse events included vomiting, elevated lipase and elevated amylase. The trial was sponsored by the NCI. Data were presented at the...

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