12:00 AM
Oct 07, 2013
 |  BC Week In Review  |  Clinical News  |  Clinical Results

Eteplirsen: Additional Phase IIb data

Additional data from 10 patients aged 7-13 with DMD in the modified intent-to-treat (mITT) population of the open-label Study 4658-US-202 extension of the double-blind, U.S. Phase IIb Study 4658-US-201 trial showed that patients who received either dose of eteplirsen for 96 weeks (30 or 50 mg/kg) had a 6.3 m reduction in mean 6MWT from baseline to week 96 compared to a 74.1 m mean reduction for patients who received placebo for 24 weeks followed by eteplirsen for an additional 72 weeks (p<=0.004). Sarepta said 1 patient in the placebo/delayed eteplirsen treatment group suffered a broken ankle unrelated to treatment and was unable to perform the 6MWT at week 84. However, the patient did perform the test at week 96. The company said his walking...

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