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12:00 AM
Jun 03, 2013
 |  BC Week In Review  |  Clinical News  |  Clinical Results

Tafinlar dabrafenib: Interim Phase I/II data

Interim data from 36 mCRC patients with V600 BRAF mutations in an open-label, U.S. and Australian Phase I/II trial showed that twice-daily 150 mg Tafinlar plus once-daily 2 mg Mekinist trametinib led to 1 complete response, 3 partial responses and 18 cases of stable disease. Median PFS was 3.5 months. The most frequent adverse events included pyrexia, nausea, fatigue, chills, vomiting, headache, peripheral edema, anemia and...

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