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Jun 03, 2013
 |  BC Week In Review  |  Clinical News  |  Clinical Results

Mekinist trametinib: Interim Phase I/II data

Interim data from 147 metastatic melanoma patients with V600 BRAF mutations in an open-label, dose-escalation, U.S. and Australian Phase I/II trial showed that twice-daily 150 mg Tafinlar dabrafenib plus once-daily 2 mg Mekinist led to a median progression-free survival (PFS) of 10.8 months in BRAF inhibitor-naïve patients in part B of the trial (n=24) and 9.4 months in BRAF inhibitor-naïve patients in part C of the trial (n=54). Tafinlar plus Mekinist led to a median PFS of 3.6 months in BRAF inhibitor-resistant patients in both part B (n=26) and part C (n=43) of the trial. In...

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