12:00 AM
Oct 22, 2012
 |  BC Week In Review  |  Clinical News  |  Clinical Results

Siponimod: Additional Phase II data

The double-blind, dose-ranging, international Phase II BOLD trial in 297 patients with RRMS showed that once-daily oral BAF312 met the primary endpoint by demonstrating a dose-response relationship in reducing the number of CUAL at 3 months (p=0.0001). Specifically, mean reductions in the number of CUAL from baseline to 3 months were 0.8 lesions for 0.25 mg BAF312, 1 lesion for 0.5 mg BAF312, 0.2 lesions for 1.25 mg BAF312, 0.5 lesions for 2 mg BAF312 and 0.4 lesions for 10 mg BAF312 vs. 1.5 lesions for placebo. Additionally, mean reductions in the number of CUAL from...

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