12:00 AM
Oct 15, 2012
 |  BC Week In Review  |  Clinical News  |  Clinical Results

Telotristat etiprate: Additional Phase II data

An open-label, dose escalation, European Phase II trial in 15 patients with metastatic carcinoid syndrome who were refractory or intolerable to somatostatin analog therapy showed that thrice-daily telotristat etiprate produced a significant median reduction of 46.4% in the number of bowel movements at week 12 compared to baseline, the primary efficacy endpoint (p<0.001). Lexicon said that the number of daily bowel movements steadily decreased over time. On secondary endpoints, 75% of patients reported an improvement in relief of carcinoid symptoms at week 12. Additionally, telotristat...

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