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ARTICLE | Clinical News

HPV E6 test: Interim data

September 26, 2011 7:00 AM UTC

Interim data from 3,179 evaluable women in the Chinese START-UP trial showed that Arbor Vita's HPV E6 Test had 99% specificity and 69.6% sensitivity for detecting CIN3+ precancerous lesions. Comparatively, visual inspection of the cervix with acetic acid (VIA) produced 94.1% specificity and 47.8% sensitivity. Additionally, the HPV E6 Test led to a ninefold reduction in the referral rate for women requiring follow-up and/or treatment compared to the digene HC2 HPV DNA test (1.5% vs. 14.3%). Furthermore, the positive predictive value (PPV) of the HPV E6 Test was 33.3% vs. 5.1% and 5.6% for the digene HC2 HPV DNA test and VIA, respectively. Data were presented at the International Papillomavirus meeting in Berlin. ...