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12:00 AM
Sep 27, 2010
 |  BC Week In Review  |  Clinical News  |  Clinical Results

Onbrez Breezhaler indacaterol: Phase III data

In the double-blind, international Phase III INSIST trial in 1,123 patients ages 40 and older, 150 µg once-daily indacaterol was superior to 50 µg twice-daily salmeterol on the primary endpoint of significantly improving FEV1 AUC from 5 minutes to 11 hours 45 minutes post-dose at week 12. Specifically, the adjusted mean difference in FEV1 AUC between treatment groups was 60 mL (p<0.001). Additionally, indacaterol was superior to salmeterol on the secondary endpoints of significantly improving trough FEV1 (p<0.001) and transition dyspnea index total score...

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