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12:00 AM
 | 
Sep 06, 2010
 |  BC Week In Review  |  Clinical News  |  Clinical Results

Mipomersen: Additional Phase III data

Additional data from the double-blind, North American Phase III RADICHOL II trial in 124 patients showed that once-weekly subcutaneous injections of 200 mg mipomersen significantly reduced APOB by 26% from baseline to week 26 vs. a 7% increase for placebo (p<0.001). Mipomersen also significantly reduced total cholesterol and non-HDL cholesterol by 19% and 25%, respectively, vs. a 4% increase in both measures for placebo (p<0.001 for both). Additionally, mipomersen significantly reduced lipoprotein(a) (LPA) by 21% vs. no change for placebo (p<0.001). Patients were already receiving a maximally-tolerated dose...

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