Alpharadin Radium-223: Additional Phase II data

In the double-blind, European Phase II BC1-03 trial in 100 patients, a single-dose of IV Alpharadin met the composite primary endpoint of a dose-dependent response in pain relief and change in analgesic consumption during a 16-week period. At 8 weeks, 5, 25, 50 and 100 kBq/kg resulted in 40%, 63%, 56% and 71% response rates, respectively. Analgesic use increased in 33% of patients in the 2 lower dose groups vs. 10% in the 2 higher dose groups. ...