Thymoglobulin rabbit anti-thymocyte globulin: Phase II

Results of a study of Thymoglobulin in inducing immunosuppression in 72 consecutive patients receiving kidneys showed less severe and less frequent rejection as compared to treatment with Atgam (p=0.014). Lymphopenia was more prolonged with Thymoglobulin, lasting more than 180 days as compared to 14 days with Atgam (p=0.012). While lymphopenia causes chills and fever, it also is indicative of the drug's action in long-term immune suppression. ...