BioCentury
ARTICLE | Clinical News

Human interleukin 1-receptor antagonist protein data

November 22, 1993 8:00 AM UTC

Company researchers and colleagues introduced the gene for IRAP into cells from the synovial lining of joints and injected the transformed synovial cells directly into the knee joints of rabbits, with successful expression of the biologically active human gene.

Animals that received their own, transformed synovial cells showed expression of the gene for five weeks, whereas those injected with cells from other rabbits lost expression by 12 days. ...