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    E.g., 2018-06-23

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14265 items
12:05 PM, Jun 06, 2018  |  BC Innovations | Distillery Therapeutics

Neurology

INDICATION: Amyotrophic lateral sclerosis (ALS) Cell culture studies suggest activating NFE2L2 could help treat ALS by promoting normal folding of mutant SOD1. Crystallographic analyses of an ALS-associated SOD1 mutant complexed with a library of cysteine-reactive...
12:05 PM, Jun 06, 2018  |  BC Innovations | Distillery Therapeutics

Infectious disease

INDICATION: Trypanosome Mouse studies identified a macrocyclic Trypanosoma rhodesain inhibitor that could help treat African trypanosomiasis. Screening of a library of cysteine protease inhibitors, in vitro activity and parasite culture assays, and structure-based optimization of...
12:04 PM, Jun 06, 2018  |  BC Innovations | Distillery Techniques

Imaging

TECHNOLOGY: PET An OX40-targeting PET imaging agent could help predict responses to immunotherapy in cancer. The agent consisted of a 64Cu radionuclide-labeled mouse mAb targeting OX40, a marker of T cell activation. In vitro, the agent...
12:04 PM, Jun 06, 2018  |  BC Innovations | Distillery Techniques

Biomarkers

TECHNOLOGY: Gene profiling A mutation in CAMK2A could help predict the risk of a previously undescribed neurodevelopmental disorder characterized by growth delay, frequent seizures and severe cognitive dysfunction. Genomic profiling of two children with the disease...
9:32 AM, Jun 06, 2018  |  BC Innovations | Translation in Brief

JAKs and clots

Brigham and Women’s Hospital researchers have uncovered the mechanisms behind a major complication in bone marrow disorders by linking a JAK-2 mutation with thrombosis in patients and mice, and identified a way to treat blood...
3:47 PM, Jun 05, 2018  |  BC Innovations | Distillery Therapeutics

Endocrine/Metabolic

INDICATION: Hypertriglyceridemia Rat studies suggest combined inhibition of MMP1 and MMP3 could help treat hypertriglyceridemia. In a rat model of diet-induced hypertriglyceridemia, subcutaneous administration of a previously reported dual MMP1/MMP3 inhibitor decreased liver weight, serum triacylglyceride,...
3:47 PM, Jun 05, 2018  |  BC Innovations | Distillery Techniques

Disease models

TECHNOLOGY: Cell models A neural network chip and an accompanying microinjection unit could be used to study retinal development and degeneration. The chip was generated by fabricating a device containing over 20,000 microwells arranged in a...
3:43 PM, Jun 05, 2018  |  BC Innovations | Distillery Therapeutics

Neurology

INDICATION: Neurology Mouse studies suggest CSF1R inhibitors could help treat age-related neurodegeneration. In a mouse model of age-related neurodegeneration, a tool compound CSF1R inhibitor decreased markers of age-related neuropathy including the numbers of thinly myelinated...
3:43 PM, Jun 05, 2018  |  BC Innovations | Distillery Therapeutics

Neurology

INDICATION: Pain Mouse studies suggest AIBP could help treat neuropathic pain. In mouse models of lipopolysaccharide (LPS)- and chemical-induced neuropathic pain, intrathecal AIBP decreased mechanical allodynia compared with vehicle. Also in the model of chemical-induced neuropathic...
3:43 PM, Jun 05, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Breast cancer An RNA-targeting small molecule that cleaves miR-96 could help treat triple-negative breast cancer (TNBC). The compound consists of a short poly(A) oligionucleotide linked to a small molecule that selectively binds the oncogenic precursor...

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