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14549 items
10:56 AM, Aug 29, 2018  |  BC Innovations | Distillery Techniques

Drug platforms; imaging

TECHNOLOGY: Structural analyses; other An electron microscopy-based method for identifying epitopes that elicit potent neutralizing antibodies could be used to guide the development of vaccines for infectious diseases. The method involves six steps: digesting animal- or...
10:56 AM, Aug 29, 2018  |  BC Innovations | Distillery Techniques

Assays and screens

TECHNOLOGY: Diagnostic assays An epigenetic-based method of quantifying blood cell types could aid the differential diagnosis of immunodeficiencies such as severe combined immunodeficiency (SCID). The method involves four steps: treating DNA isolated from patient blood samples...
10:55 AM, Aug 29, 2018  |  BC Innovations | Distillery Therapeutics

Inflammation

INDICATION: Inflammation Cell culture, mouse, rat and dog studies identified a RORγT inverse agonist that could help treat inflammation. Chemical synthesis and screening of a subset of Pfizer Inc.’s small compound library in a HEK-cell based...
10:55 AM, Aug 29, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Lung cancer Patient sample, cell culture and mouse studies suggest inhibiting KMT5A could help treat lung squamous cell carcinoma (SCC). In tumor samples from patients, BCL11A and SOX2 expression levels were higher than in matched...
10:55 AM, Aug 29, 2018  |  BC Innovations | Distillery Therapeutics

Infectious disease

INDICATION: Bacterial infection Mouse studies suggest antagonizing PTGER4 could help treat infectious colitis. In a mouse model of Citrobacter rodentium-induced colitis, a PTGER4 antagonist tool compound decreased weight loss, numbers of infectious bacteria in the colon,...
10:54 AM, Aug 29, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Breast cancer Patient sample, cell culture and mouse studies suggest IL-1β or promoting ZEB1 expression could help treat metastatic breast cancer. In 1,379 patients with breast cancer, high primary tumor levels of IL-1β were associated...
10:54 AM, Aug 29, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Cancer Mouse studies identified a cyclic lipodepsipeptide (CLD) that could help treat cancer. In mice with mouse embryo fibroblast-induced foot tumors, a previously reported CLD containing a 4-amido-2,4-pentadienoate substructure decreased tumor growth compared with vehicle....
10:53 AM, Aug 29, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Cervical cancer; skin cancer Mouse studies suggest a vaccine based on a nanoparticle-HpV16gp2 peptide conjugate could help treat human papillomavirus (HPV)-associated cancers. The conjugate consists of nanoparticles with a polypropylene sulfide core and HpV16gp2 peptides...
10:52 AM, Aug 29, 2018  |  BC Innovations | Distillery Therapeutics

Musculoskeletal

INDICATION: Myotonic dystrophy type 1 (DM1) Cell culture and mouse studies suggest inhibiting miR-23b and miR-218 could help treat DM1. In myoblast cells from a DM1 patient, miR-23b and miR-218 antagomirs decreased disease-associated splicing defects...
10:52 AM, Aug 29, 2018  |  BC Innovations | Distillery Therapeutics

Infectious disease

INDICATION: Sepsis Cell culture and mouse studies identified a GSDMD inhibitor that could help treat sepsis. In vitro, the previously identified necroptosis inhibitor necrosulfamide bound GSDMD with a Kd of 32 μM. In mouse bone...

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