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14318 items
12:23 PM, Jun 20, 2018  |  BC Innovations | Distillery Techniques

Drug platforms

TECHNOLOGY: Gene therapy A four-compound cocktail could enhance the efficiency of CRISPR-based editing in pluripotent stem cells. The method involves CRISPR-based editing in pluripotent stem cells with systems based on CRISPR from Prevotella and Francisella 1...
12:23 PM, Jun 20, 2018  |  BC Innovations | Distillery Techniques

Biomarkers

TECHNOLOGY: Tissue markers Low esophageal levels of SPINK7 could help diagnose eosinophilic esophagitis. In esophageal tissue samples, SPINK7 protein and mRNA levels were lower in patients with eosinophilic esophagitis than in healthy volunteers, and the low...
12:22 PM, Jun 20, 2018  |  BC Innovations | Distillery Techniques

Drug delivery; drug platforms

TECHNOLOGY: Other; gene therapy Caffeine-sensitive cell implants could be used to deliver gene therapies for diabetes and other diseases. The implants were generated by constructing a plasmid encoding a single-domain camelid antibody that homodimerizes in the...
12:22 PM, Jun 20, 2018  |  BC Innovations | Distillery Techniques

Drug platforms

TECHNOLOGY: Gene therapy MDM2-mediated inhibition of p53 could enhance the efficiency of gene insertions using CRISPR-Cas9. The modified CRISPR protocol includes treating cell culture with the p53 inhibitor MDM2, followed by administration of ribonucleoprotein complexes containing...
12:21 PM, Jun 20, 2018  |  BC Innovations | Distillery Techniques

Biomarkers

TECHNOLOGY: SNPs Seven SNPs on SYNJ1 could help predict outcomes in familial AD. Genome-wide association studies (GWAS) in 305 early-onset and 2,199 late-onset familial AD patients identified four SNPs in SYNJ1 associated with rapid disease onset...
12:21 PM, Jun 20, 2018  |  BC Innovations | Distillery Techniques

Drug platforms

TECHNOLOGY: Cell therapy A method utilizing click chemistry to generate injectable hydrogels containing cross-linked cells could be used in regenerative therapies. The method generates hydrogels containing cross-linked cells in three steps: metabolic incorporation of azide groups...
12:21 PM, Jun 20, 2018  |  BC Innovations | Distillery Techniques

Drug delivery

TECHNOLOGY: Nanoparticles Photothermal-activated nanoparticles could be used for sequential delivery of chemotherapy and photothermal therapy for cancer. The nanoparticles consist of an inner porous silica shell containing a palladium (II)-based photothermal agent which emits heat in...
12:20 PM, Jun 20, 2018  |  BC Innovations | Distillery Techniques

Disease models

TECHNOLOGY: Cell models Human airway epithelium derived from organoids could be used to model pulmonary viral infections and screen therapies to treat them. The airway epithelium was generated in four steps: culturing human lung-derived cells in...
12:20 PM, Jun 20, 2018  |  BC Innovations | Distillery Techniques

Biomarkers

TECHNOLOGY: Plasma markers Levels of miR-301a in serum-derived exosomes could help diagnose and predict progression in pancreatic cancer. In serum-derived exosomes from 50 patients, miR-301a levels were higher than in serum-derived exosomes from 12 healthy...
12:19 PM, Jun 20, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Brain cancer Patient sample, cell culture and mouse studies suggest inhibiting AMPK could help treat glioma. In tumor samples from glioblastoma and low-grade glioma patients, levels of activated AMPK were higher than in brain tissue...

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