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    E.g., 2018-06-27

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14161 items
8:30 AM, May 09, 2018  |  BC Innovations | Distillery Techniques

Biomarkers

TECHNOLOGY: Tissue markers CSF levels of AVP could help diagnose ASD. In CSF samples from seven male children with ASD, AVP levels were lower than in samples from six pediatric acute lymphoblastic leukemia (ALL) patients and...
8:27 AM, May 09, 2018  |  BC Innovations | Distillery Techniques

Biomarkers

TECHNOLOGY: SNPs SNPs on 44 genomic loci could help predict the risk of MDD. Genome-wide association studies (GWAS) in 135,458 patients with MDD and 344,901 unaffected subjects identified associations between the disease and SNPs on 44...
8:26 AM, May 09, 2018  |  BC Innovations | Distillery Techniques

Biomarkers

TECHNOLOGY: Plasma markers Serum levels of miR-940, miR-451a, miR-16-5p and miR-17-3p could help predict response to Herceptin trastuzumab in HER2 (EGFR2; ErbB2; neu)-positive metastatic breast cancer patients. In 283 HER2-positive metastatic breast cancer patients receiving Herceptin,...
8:25 AM, May 09, 2018  |  BC Innovations | Distillery Techniques

Drug platforms

TECHNOLOGY: Cell therapy Peripheral T cells engineered to express tumor-derived TCRs could help treat ovarian cancer. The cells are generated by deriving TCR libraries from frozen tumor samples from ovarian cancer patients, assembling and cloning cassettes...
8:24 AM, May 09, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Prostate cancer Patient sample, cell culture and chicken embryo studies suggest inhibiting FZD8 could help treat prostate cancer. In patient samples, levels of FZD8 were higher in tumors than in adjacent normal prostate tissue. In...
8:22 AM, May 09, 2018  |  BC Innovations | Distillery Therapeutics

Dermatology

INDICATION: Itch Mouse studies suggest activating Merkel cells could help treat itch. In a mouse model of age-related dry skin-induced itch, numbers of epidermal Merkel cells were lower than in normal mice. Also in the model,...
8:22 AM, May 09, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Breast cancer Patient sample and cell culture studies suggest inhibiting BARD1, BRCA1, CDK1 or CKD12 could help treat tamoxifen-resistant breast cancer. In tumor tissue from 27 recurrent breast cancer patients whose tumors became resistant...
8:20 AM, May 09, 2018  |  BC Innovations | Distillery Therapeutics

Musculoskeletal

INDICATION: Muscular dystrophy Mouse studies suggest that COX-2 inhibition could help treat Duchenne muscular dystrophy (DMD). In a mouse model of DMD, the COX-2 inhibitor Celebrex celecoxib decreased immune cell infiltration in tibialis anterior muscle and...
8:20 AM, May 09, 2018  |  BC Innovations | Distillery Therapeutics

Otologic

INDICATION: Hearing loss Mouse studies suggest optogenetic therapy using an engineered mutant of the C. noctigama channelrhodopsin Chrimson could help treat age-related hearing loss. The mutant is a version of Chrimson engineered to inactivate quickly...
8:20 AM, May 09, 2018  |  BC Innovations | Distillery Therapeutics

Gastrointestinal

INDICATION: Pancreatitis Mouse studies suggest PIEZO1 inhibition could help treat pancreatitis. In a mouse model of pressure-induced acute pancreatitis, pancreatic acinar cell-specific knockout of PIEZO1 or the PIEZO1 inhibitor AT-300 decreased histological disease scores and levels...

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