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    E.g., 2018-11-17

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14756 items
1:33 PM, Oct 31, 2018  |  BC Innovations | Distillery Techniques

Disease models

TECHNOLOGY: Animal models E-cadherin (CDH1)-deficient mice with activated PI3KCA could be used to screen therapies for invasive lobular breast carcinoma. Mice engineered to express mutant, inactive CHD1 and constitutively active PI3KCA recapitulated multiple features of human...
1:32 PM, Oct 31, 2018  |  BC Innovations | Distillery Techniques

Disease models

TECHNOLOGY: 3-D models Patient-derived high-grade serous cancer (HGSC) organoids could be used to help predict individual patient responses to DNA repair inhibitors in ovarian cancer. The organoids are generated by culturing solid tumor cells extracted...
1:32 PM, Oct 31, 2018  |  BC Innovations | Distillery Techniques

Biomarkers

TECHNOLOGY: Plasma markers The numbers of circulating hybrid leukocyte-epithelial cells expressing PTPRC and creatine kinase could help predict survival in pancreatic cancer. In 18 patients, high numbers of the hybrid cells expressing PTPRC and creatine kinase...
1:31 PM, Oct 31, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Pancreatic cancer Patient sample, cell culture and mouse studies suggest inhibiting PIN1 could help treat pancreatic ductal adenocarcinoma (PDAC). In patients, PIN1 levels were higher in tumor samples than in adjacent normal tissue samples and...
1:30 PM, Oct 31, 2018  |  BC Innovations | Distillery Therapeutics

Other

INDICATION: Poisoning Mouse studies suggest a topical pyridine-2-aldoxime-based gel could help treat pesticide poisoning. The gel contains pyridine-2-aldoxime, which reverses binding and inactivation of AChE by pesticides, linked via an acetamide bridge to chitosan to functionalize...
1:30 PM, Oct 31, 2018  |  BC Innovations | Distillery Therapeutics

Neurology

INDICATION: Cognitive dysfunction Mouse studies suggest inhibiting ACE could help treat lupus-associated cognitive dysfunction. In hippocampal tissue samples from a mouse model of the indication, ACE expression was higher than in samples from normal mice. Also...
1:29 PM, Oct 31, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Brain cancer In silico, cell culture and mouse studies suggest digoxin could help treat group 3 or 4 medulloblastoma. In silico screening of 1,309 FDA-approved small molecule drugs for compounds predicted to modulate highly active...
1:28 PM, Oct 31, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Prostate cancer Cell culture studies identified an oligomer macrocycle-based inhibitor of the β-catenin-TCF4 interaction that could help treat prostate cancer. Chemical synthesis of oligomer macrocycles designed to inhibit the interaction between TCF4 and β-catenin, and...
1:27 PM, Oct 31, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Brain cancer; lung cancer Mouse studies suggest LPA could enhance the efficacy of chemotherapies and anti-PD-1 immunotherapies to treat brain and lung cancers. In a mouse model of glioma, LPA plus the generic chemotherapy temozolomide...
1:26 PM, Oct 31, 2018  |  BC Innovations | Distillery Therapeutics

Hepatic; renal

INDICATION: Liver disease; renal damage Cell culture and mouse studies suggest inhibiting ACMSD could help prevent non-alcoholic fatty liver disease (NAFLD) and acute kidney injury (AKI). In mouse primary hepatocytes, the ACMSD inhibitor TES-991 decreased...

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