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14756 items
11:44 AM, Nov 06, 2018  |  BC Innovations | Distillery Techniques

Assays and screens; biomarkers

TECHNOLOGY: Cellular assays; gene profiling A genome editing method could help identify gene variants that confer a clinically relevant risk of breast and ovarian cancers. The assay involves using CRISPR-based saturation genome editing to introduce all...
9:10 AM, Nov 02, 2018  |  BC Innovations | Distillery Techniques

Other

TECHNOLOGY: Computational model A computational model of drug-target interactions could help companies predict the off-target effects of drug compounds and identify new targets for them while keeping the source data confidential. The model is trained...
8:19 PM, Nov 01, 2018  |  BC Innovations | Targets & Mechanisms

FDA’s pediatric target picks

FDA is looking ahead of industry in its guideline on targets for pediatric oncology, which includes more than 50 not yet in company pipelines in a list of over 220 the agency has its eye...
7:50 PM, Nov 01, 2018  |  BC Innovations | Targets & Mechanisms

Rethinking definitions of autoimmune disease

The autoimmune field is dialing up its search for better biomarkers as it seeks to make the next step change from the targeted therapies that overtook blanket immunosuppressants. The question is whether autoimmunity might follow...
3:22 PM, Nov 01, 2018  |  BC Innovations | Translation in Brief

New Therapeutic Targets and Biomarkers: October 2018

New Therapeutic Targets and Biomarkers: October 2018 Select top therapeutic targets and biomarkers covered by BioCentury or added to the BCIQ database during October. Therapeutic targets are defined as any protein, gene or other molecule that...
12:46 PM, Nov 01, 2018  |  BC Innovations | Emerging Company Profile

Secarna’s next-gen oligos

Secarna Pharmaceuticals GmbH’s antisense oligonucleotides for immuno-oncology could have better tissue penetration than small molecules and antibodies against the same targets. The company was established in 2015 by the founders and investors who launched antisense...
12:18 PM, Nov 01, 2018  |  BC Innovations | Translation in Brief

Private sharing

A new cryptographic computational protocol from the Massachusetts Institute of Technology will allow drug companies to pool data for predictive modeling of drug-target interactions without revealing the underlying drugs, targets or observed interactions. The method...
3:20 PM, Oct 31, 2018  |  BC Innovations | Translation in Brief

Programming cell circuits

Two synthetic biology teams have developed methods to regulate cell behavior at the protein level using viral proteases. The work could aid the development of conditionally activated cancer therapies that bypass the risk of insertional...
1:33 PM, Oct 31, 2018  |  BC Innovations | Distillery Techniques

Imaging; other

TECHNOLOGY: Other; computational models Computer-assisted interpretation of X-ray radiographs could help diagnose bone fractures. The detection system involves processing radiographs, calculating the probability of a visible fracture, and overlaying the putative fracture location with a heat...
1:33 PM, Oct 31, 2018  |  BC Innovations | Distillery Techniques

Biomarkers

TECHNOLOGY: SNPs Variants in NUS1 could help predict the risk of early-onset PD. Whole-exome sequencing of 39 early-onset PD patients, their parents and unaffected siblings identified associations between the disease and variants on 12 genes,...

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