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14318 items
10:46 AM, Jun 28, 2018  |  BC Innovations | Distillery Techniques

Disease models

TECHNOLOGY: 3-D models Patient-derived metastatic neuroendocrine prostate cancer organoids could be used to screen therapies for personalized medicine applications. The organoids are generated by culturing enzyme-dissociated cells from samples of a patient’s liver, lymph node and...
10:46 AM, Jun 28, 2018  |  BC Innovations | Distillery Techniques

Assays and screens; chemistry; drug platforms

TECHNOLOGY: Binding assays; tool compounds; antibody scaffolds A method for generating and screening synthetic nanobodies could be used to identify compounds that bind membrane proteins in a conformation-specific manner, for use as therapeutics or research tools....
10:46 AM, Jun 28, 2018  |  BC Innovations | Distillery Techniques

Drug platforms

TECHNOLOGY: Cell therapy CAR T cells with six ITAMS could have greater activity towards cancer cells than CAR T cells with the standard three ITAMS. The cells are generated by duplicating the CD3ζ (CD3z; CD247)...
6:34 PM, Jun 21, 2018  |  BC Innovations | Targets & Mechanisms

T cell balancing act

Among the improvements to next-generation CAR T cell therapies is the need to optimize the ratios of the different T cell subsets. While CD8+ T cells have grabbed most of the attention, a study from...
4:59 PM, Jun 21, 2018  |  BC Innovations | Product R&D

Tusk’s take on CD25

As companies revisit the potential of IL-2 to aid cancer immunotherapy, Tusk Therapeutics Ltd. has a new take by attacking CD25, a component of the IL-2 receptor with its own storied past. Its antibody could...
2:10 PM, Jun 21, 2018  |  BC Innovations | Translation in Brief

Liver’s killer instinct

A study in Science suggests natural killer T cells residing in the liver uniquely position the organ to reap antitumor effects from antibiotic-mediated microbiome depletion, uncovering a novel link in the microbiome-cancer relationship that highlights...
11:29 AM, Jun 21, 2018  |  BC Innovations | Emerging Company Profile

Getting past PTSD

Neurovation Labs Inc. is developing a GRIA1-targeting tracer and a small molecule therapy that could provide an objective diagnosis of PTSD and treat the underlying disease instead of just its symptoms. Post-traumatic stress disorder (PTSD) is...
9:49 AM, Jun 21, 2018  |  BC Innovations | Translation in Brief

PHIP the script

Cancers lacking key molecular signatures targeted by precision therapies are among the most challenging to treat, but a new study has identified a target, PHIP, for three of those difficult tumor types. A group led...
2:02 PM, Jun 20, 2018  |  BC Innovations | Translation in Brief

Alterations made to measure

Taking its gene editing services a step farther than other service providers that offer CRISPR editing tools and standard pre-edited cell lines, Synthego Corp. launched a portfolio of customized CRISPR-edited cell products. The new offering...
12:24 PM, Jun 20, 2018  |  BC Innovations | Distillery Techniques

Drug platforms

TECHNOLOGY: Cell therapy Complex tissue fragments incorporating MSCs and HUVECs could enhance the engraftment of transplanted tissues. The complex tissue fragments are generated by: treating select tissue samples with collagenase to generate tissue fragments; co-culturing the...

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