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14161 items
11:06 AM, May 15, 2018  |  BC Innovations | Distillery Therapeutics

Ophthalmic disease

INDICATION: Retinitis Mouse studies suggest promoting expression of the proteasome subunits PSME1 or PSMD11 could help treat retinitis pigmentosa. In a mouse model of the disease, overexpression of PSME1 or PSMD11 increased photoreceptor survival and light...
7:06 PM, May 10, 2018  |  BC Innovations | Finance

Amplifying oligos

The last five years have seen a steady stream of preclinical deals for antisense, siRNA and mRNA therapies that suggests pharmas are taking the modalities seriously as alternatives to traditional small molecules and antibodies. But...
2:31 PM, May 10, 2018  |  BC Innovations | Emerging Company Profile

Abac’s precision platform

Abac Therapeutics S.A. is taking a precision approach to treat bacterial infections that could avoid the development of drug resistance that plagues broad-spectrum antibiotics. The company’s PasNas platform uses phenotypic and in vitro assays to screen...
11:54 AM, May 10, 2018  |  BC Innovations | Strategy

Finding phenotype

NIH wants to find direct relationships between genes and disease more efficiently than GWAS or other standard approaches allow. The institute has teamed up with Inova Health System to create a searchable pool of genomes...
2:12 PM, May 09, 2018  |  BC Innovations | Translation in Brief

The fate of NK cells

New research is elucidating the relationship between CAR-transfected NK cells’ differentiation states and their cancer-killing potential -- knowledge that Fate Therapeutics Inc. (NASDAQ:FATE) is leveraging for its own cell therapies. In a study published in Cancer...
1:03 PM, May 09, 2018  |  BC Innovations | Distillery Techniques

Drug delivery

TECHNOLOGY: Nanoparticles Cell-penetrating peptide-based nanoparticles could be used to deliver CRISPR-Cas9 machinery for cancer. The nanoparticles consist of a cationic α-helical cell-penetrating peptide and serum stability-enhancing polyethylene glycol (PEG) loaded with a plasmid vector encoding Cas9...
1:03 PM, May 09, 2018  |  BC Innovations | Distillery Techniques

Chemistry; drug platforms

TECHNOLOGY: Biosynthesis; expression systems A Saccharomyces cerevisiae-based heterologous gene expression platform could facilitate the search for drug-like compounds. The platform involves four steps: using bioinformatics to identify potentially functional biosynthetic gene clusters, such as polyketide gene...
1:02 PM, May 09, 2018  |  BC Innovations | Distillery Therapeutics

Cardiovascular; pulmonary

INDICATION: Myocardial infarction (MI); acute lung injury Patient sample and mouse studies suggest inhibiting CAMP could help treat MI and acute lung injury (ALI). In thrombus samples from MI patients, CAMP was highly expressed, and in...
1:01 PM, May 09, 2018  |  BC Innovations | Distillery Therapeutics

Renal; cardiovascular; hepatic

INDICATION: Renal failure; heart failure; liver failure Mouse studies suggest inhibiting YY1 or its co-repressor FKBP12 could help treat chronic renal, heart and liver failure. In a mouse model of urethral obstruction-induced chronic renal failure, a...
11:58 AM, May 09, 2018  |  BC Innovations | Translation in Brief

Dissecting rare gliomas

In an April Science study, researchers from Massachusetts General Hospital and Harvard Medical School identified a subpopulation of malignant cells driving disease progression in rare pediatric gliomas with mutated histone H3 K27M using single-cell RNA...