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14260 items
11:18 AM, Jun 13, 2018  |  BC Innovations | Distillery Therapeutics

Ophthalmic disease

INDICATION: Retinitis; ophthalmic In vitro, mouse and cell culture studies identified a mutant RHO-stabilizing compound that could help treat retinal degeneration and autosomal dominant retinitis pigmentosa (adRP). High throughput screening and testing in a ligand-binding assay...
11:18 AM, Jun 13, 2018  |  BC Innovations | Distillery Therapeutics

Cardiovascular

INDICATION: Heart failure Patient sample and cell culture studies suggest inhibiting microtubule detyrosination or promoting expression of tubulin tyrosine ligase (TTL) could help treat heart failure. In left ventricular tissue samples from patients, the density of...
11:18 AM, Jun 13, 2018  |  BC Innovations | Distillery Therapeutics

Endocrine/Metabolic

INDICATION: Hypercholesterolemia Patient sample and mouse studies suggest inhibiting LIMA1 could help treat hypercholesterolemia. Whole-genome sequencing of patient plasma samples identified an association between a rare frameshift variant of LIMA1 and low levels of LDL-C...
11:17 AM, Jun 13, 2018  |  BC Innovations | Distillery Therapeutics

Neurology

INDICATION: Parkinson’s disease (PD) Cell culture and fruit fly studies suggest promoting NAD+ synthesis could help treat PD caused by GBA mutations. In neurons generated via induced pluripotent stem (iPS) cells from a patient harboring a...
11:17 AM, Jun 13, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Liver cancer, colorectal cancer Cell culture and mouse studies suggest inhibiting CPT1A alone or in combination with VEGF inhibition could help treat hepatocellular carcinoma and colorectal cancer. In a mouse colorectal cancer cell line cultured...
11:17 AM, Jun 13, 2018  |  BC Innovations | Distillery Therapeutics

Infectious disease

INDICATION: Staphylococcus Cell culture and mouse studies suggest a PEG-based hydrogel loaded with lysostaphin could help treat orthopedic implant Staphylococcus infections. The antimicrobial enzyme lysostaphin is encapsulated in a hydrogel consisting of four-arm PEG macromers that...
8:35 AM, Jun 12, 2018  |  BC Innovations | Translation in Brief

A glioblastoma feature story

The Ivy Glioblastoma Atlas Project has added anatomically based expression patterns to the growing body of transcriptional atlases, and the results are being used to pinpoint intratumor regions as therapeutic targets. Led by the Allen Institute...
6:36 PM, Jun 07, 2018  |  BC Innovations | Tools & Techniques

NK cell check-in

Until recently, there’s been scarce overlap between the NK cell field and the world of checkpoint inhibitors, with the former focused on cell therapies to kill tumor cells directly and the latter on relieving immune...
4:40 PM, Jun 07, 2018  |  BC Innovations | Finance

Deerfield goes to school

Deerfield’s fourth umbrella agreement in the last eight months is a sign the firm is getting serious about creating newcos from academic discoveries. It thinks that with preset terms and unanimous buy-in, the model provides...
4:28 PM, Jun 07, 2018  |  BC Innovations | Translation in Brief

New Therapeutic Targets and Biomarkers: May 2018

New Therapeutic Targets and Biomarkers: May 2018 Select top therapeutic targets and biomarkers covered by BioCentury or added to the BCIQ database during May 2018. Therapeutic targets are defined as any protein, gene or other molecule...

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