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14549 items
12:32 PM, Sep 10, 2018  |  BC Innovations | Distillery Therapeutics

Infectious disease

INDICATION: Dengue fever Cell culture and rat studies identified an indole-based compound that could help treat dengue fever. Chemical synthesis and testing of indole analogs in monkey kidney cell-based assays yielded four compounds that inhibited replication...
12:31 PM, Sep 10, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Melanoma; colorectal cancer Cell culture and mouse studies suggest MLKL mRNA plus electroporation could help treat melanoma and colorectal cancer. In a mouse melanoma cell line and three human melanoma cell lines, transfection with MLKL...
12:31 PM, Sep 10, 2018  |  BC Innovations | Distillery Therapeutics

Neurology

INDICATION: Pain Mouse studies suggest inhibiting the USP5-CACNA1H interaction could help treat postsurgical pain. In a mouse model of incisional pain, shRNA targeting of USP5 or systemic knockout of CACNA1H decreased mechanical allodynia compared with vehicle...
12:30 PM, Sep 10, 2018  |  BC Innovations | Distillery Therapeutics

Infectious disease

INDICATION: Influenza virus Mouse, rabbit and ferret studies suggest vaccines based on modified HA mRNA could help prevent infection by multiple strains of influenza A virus. The two vaccines consist of mRNA encoding HA from...
12:30 PM, Sep 10, 2018  |  BC Innovations | Distillery Therapeutics

Hematology

INDICATION: Bleeding Cell culture and mouse studies suggest inhibiting STAB2 could help treat von Willebrand disease, which is caused by deficiencies in the Factor VIII carrier vWF. In a mouse model of von Willebrand disease infused...
12:30 PM, Sep 10, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Lung cancer Patient sample and mouse studies suggest promoting the expression of KIF16B, SELENOW and TESK2 could help prevent brain metastasis in lung cancer. In patients, low expression of KIF16B, SELENOW and TESK2 in primary...
12:29 PM, Sep 10, 2018  |  BC Innovations | Distillery Techniques

Drug platforms

TECHNOLOGY: Gene therapy Extension and chemical modification of the 5’ end of CRISPR RNAs (crRNAs) could enhance the editing efficiency and serum stability of CRISPR-Cas12a-based gene therapies. The method involves modifying crRNAs at the 5’ end...
12:28 PM, Sep 10, 2018  |  BC Innovations | Distillery Techniques

Disease models

TECHNOLOGY: 3-D models Patient-derived oligocortical spheroids could be used to study demyelinating diseases and screen therapies to treat them. The spheroids were generated by culturing human pluripotent stem cells with platelet derived growth factor AA (PDGFAA),...
12:27 PM, Sep 10, 2018  |  BC Innovations | Distillery Techniques

Assays and screens; other

TECHNOLOGY: Cellular assays; computational models An algorithm based on cytometric data from multiple studies could help identify cell populations as diagnostic or prognostic markers of disease. The algorithm involves three steps. First, it processes raw...
12:27 PM, Sep 10, 2018  |  BC Innovations | Distillery Techniques

Drug delivery

TECHNOLOGY: Nanoparticles Nanoparticles bound to red blood cells (RBCs) could be used to deliver drugs to the vasculature of specific organs. The method involves mixing bare nanogels with ex vivo RBCs to enable RBC-nanoparticle binding, then...

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