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13798 items
9:11 AM, Feb 06, 2018  |  BC Innovations | Distillery Techniques

Assays and screens; biomarkers

TECHNOLOGY: Cell-free assays; plasma markers A composite measure of Aβ40, Aβ42 and APP669-711 levels in plasma that determines the brain burden of β amyloid could help stratify AD and MCI patients in clinical trials. In plasma...
9:09 AM, Feb 06, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Colorectal cancer Patient sample, cell culture and mouse studies suggest inhibiting HHAT could help treat colorectal cancer. In colorectal cancer cells from patients, siRNA targeting HHAT decreased spheroid formation and size compared with non-specific...
9:09 AM, Feb 06, 2018  |  BC Innovations | Distillery Therapeutics

Infectious disease

INDICATION: Zika virus Mouse studies suggest inhibiting PERK or IRE1 could help prevent embryonic microcephaly caused by Zika infection. In a mouse embryo model of Zika infection, tool compound PERK or IRE1 inhibitors decreased microcephaly compared...
9:08 AM, Feb 06, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Endometrial cancer Cell culture and mouse studies suggest combining paclitaxel-loaded nanoparticles and the multikinase inhibitor Vargatef nintedanib could help treat p53-deficient endometrial cancer. In a p53-deficient human endometrial cancer cell line, paclitaxel-loaded nanoparticles plus...
9:08 AM, Feb 06, 2018  |  BC Innovations | Distillery Therapeutics

Endocrine / Metabolic

INDICATION: Diabetes Mouse studies suggest inhibiting DLL4 could help treat diabetes. In a mouse model of diabetes, an anti-DLL4 antibody decreased hyperglycemia compared with a control antibody. In another mouse model of diabetes, the anti-DLL4 antibody...
9:08 AM, Feb 06, 2018  |  BC Innovations | Distillery Therapeutics

Autoimmune disease

INDICATION: Multiple sclerosis (MS) Cell culture and mouse studies suggest the selective serotonin reuptake inhibitor (SSRI) clomipramine could help treat MS. Screening a library of oral generic drugs that cross the blood-brain barrier (BBB) in a...
9:07 AM, Feb 06, 2018  |  BC Innovations | Distillery Therapeutics

Infectious disease

INDICATION: Influenza virus Mouse studies suggest a protein nanoparticle vaccine based on M2e, HA1 and HA2 could help prevent influenza A virus infection. The vaccine consists of a mixture of nanoparticles, all having the same protein...
9:03 AM, Feb 06, 2018  |  BC Innovations | Distillery Therapeutics

Endocrine / Metabolic

INDICATION: Diabetes Mouse studies suggest promoting FAM13A expression could help treat obesity-related diabetes. In a mouse model of high-fat diet-induced obesity, FAM13A levels in adipose tissue were higher than in mice fed a normal diet. Also...
9:03 AM, Feb 06, 2018  |  BC Innovations | Distillery Therapeutics

Autoimmune disease

INDICATION: Multiple sclerosis (MS) Mouse studies suggest IL-33 could help treat MS. In brain samples from the experimental autoimmune encephalomyelitis (EAE) mouse model of MS, mast cell levels of IL-33 were lower in female mice than...
9:02 AM, Feb 06, 2018  |  BC Innovations | Distillery Therapeutics

Infectious disease

INDICATION: Tuberculosis Non-human primate studies suggest a vaccine based on cytomegalovirus (CMV) expressing six M. tuberculosis antigens could help prevent tuberculosis (TB). The vaccine consists of six bacterial antigens -- M. tuberculosis fbpA, esxA, vapB47, Rv2626,...

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