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    E.g., 2018-11-17

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14756 items
12:44 PM, Nov 06, 2018  |  BC Innovations | Distillery Therapeutics

Infectious disease

INDICATION: Clostridium In vitro and mouse studies identified an inhibitor of C. difficile TcdB that could help treat C. difficile infection (CDI). Chemical synthesis and in vitro testing of hexakisphosphate analogs of inositol yielded a compound...
12:44 PM, Nov 06, 2018  |  BC Innovations | Distillery Therapeutics

Neurology

INDICATION: Neurology In vitro, cell culture and mouse studies identified a PANK3 activator that could help treat pantothenate kinase-associated neurodegeneration (PKAN), which is caused by PANK2 deficiency and leads to low Coenzyme A levels in neuronal...
12:44 PM, Nov 06, 2018  |  BC Innovations | Distillery Therapeutics

Ophthalmic disease

INDICATION: Retinitis Patient sample studies suggest CRISPR-mediated editing of PRPF31 could help treat retinitis pigmentosa caused by a loss-of-function point mutation in the gene. In retinal pigment epithelium cells and photoreceptors of retinal organoids derived from...
12:43 PM, Nov 06, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Adenocarcinoma Mouse studies suggest dual inhibition of MCL1 and MEK could help treat KRAS-mutant adenocarcinoma. In seven patient-derived xenograft (PDX) mouse models of KRAS-mutant adenocarcinoma, the MCL1 inhibitor AMG 176 plus the MEK inhibitor...
11:46 AM, Nov 06, 2018  |  BC Innovations | Distillery Techniques

Drug platforms

TECHNOLOGY: Gene therapy Streptococcus canis Cas9 could be used for CRISPR-based gene editing of a wider range of DNA targets than S. pyogenes Cas9. In a human cell line, S. canis Cas9 had higher activity at...
11:46 AM, Nov 06, 2018  |  BC Innovations | Distillery Techniques

Drug delivery

TECHNOLOGY: Viral vectors IL-1β and IL-6 inhibitors could help reduce immune responses to AAV vectors used for gene therapies. In peripheral blood mononuclear cell (PBMC) cultures from healthy volunteers, AAV serotype 2 (AAV2) peptide antigens increased...
11:46 AM, Nov 06, 2018  |  BC Innovations | Distillery Techniques

Assays and screens

TECHNOLOGY: Diagnostic assays Serum levels of two 10-miRNA panels could help diagnose ovarian tumors. In a cohort of 333 patients with ovarian cancers, 66 with borderline ovarian tumors, 29 with benign ovarian tumors, 859 with...
11:45 AM, Nov 06, 2018  |  BC Innovations | Distillery Techniques

Assays and screens; biomarkers

TECHNOLOGY: Cellular assays; gene profiling; tissue markers Gene profiling coupled with cell-based assays of patient samples could help predict drug responses in AML patients. In tumor samples from 363 patients, whole-exome sequencing plus genotyping of nucleophosmin...
11:44 AM, Nov 06, 2018  |  BC Innovations | Distillery Techniques

Drug delivery

TECHNOLOGY: Targeting domains Conjugating ASOs to a GLP-1R agonist construct could enhance the delivery of antisense therapies to pancreatic islet β cells for metabolic diseases. The conjugates consist of 5’-hexylamino ASOs against the selected therapeutic targets...
11:44 AM, Nov 06, 2018  |  BC Innovations | Distillery Techniques

Biomarkers; other

TECHNOLOGY: SNPs; gene profiling; computational models A machine learning-based method could help distinguish true SNPs or indels identified by next-generation sequencing (NGS) from errors introduced by the underlying NGS technology. The method involves five steps: converting...

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