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13798 items
2:53 PM, Feb 08, 2018  |  BC Innovations | Translation in Brief

Diverging pathways

Results from a National Cancer Institute study could explain disparities in treatment outcomes for African-Americans, who have the highest lung cancer incidence and mortality rates of any racial group. The study, published in Clinical Cancer Research...
8:29 AM, Feb 07, 2018  |  BC Innovations | Distillery Techniques

Biomarkers

TECHNOLOGY: SNPs; plasma markers Loss-of-function mutations in SLC7A8 could help predict the risk of age-related hearing loss. Whole-genome sequencing in blood samples from 66 age-related hearing loss patients and 81 healthy, elderly volunteers identified four loss-of-function...
8:29 AM, Feb 07, 2018  |  BC Innovations | Distillery Techniques

Drug delivery

TECHNOLOGY: Nanoparticles Polyamine-based nanoparticles loaded with AGO2 could be used as delivery vehicles for therapeutic siRNA. The nanoparticles consist of a polyamine capsule containing a therapeutic siRNA and AGO2, an RNA-induced silencing complex (RISC)-interacting protein that...
8:29 AM, Feb 07, 2018  |  BC Innovations | Distillery Techniques

Drug platforms

TECHNOLOGY: Cell therapy CAR T cells engineered to contain a JAK-STAT signaling domain could enhance proliferation and persistence of T cell therapies for cancer. The engineered CAR T cells consisted of standard CD19-targeting CARs engineered with...
8:28 AM, Feb 07, 2018  |  BC Innovations | Distillery Techniques

Drug platforms

TECHNOLOGY: Gene therapy Engineered, chimeric DNA-RNA guide nucleic acids could be used for CRISPR-based gene editing with fewer off-target effects than standard guide RNAs (gRNAs). The chimeric guides consist of standard gRNAs that have 10 RNA...
8:27 AM, Feb 07, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Lung cancer Cell culture and mouse studies suggest inhibiting RAF1 could help treat KRAS-driven lung cancer. In tumor cells from two patient-derived xenograft (PDX) mouse models of KRAS-driven lung cancer, shRNA targeting RAF1 encoded in...
8:27 AM, Feb 07, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Breast cancer Patient sample and mouse studies suggest inhibiting IL-1α or IL-6 could help treat HER2-positive breast cancer. In patient tumor samples, levels of IL-1α or IL-6 were associated with poor metastasis-free survival, and high...
8:25 AM, Feb 07, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Lymphoma; breast cancer; colorectal cancer Mouse studies suggest intratumoral injection of a TLR9 agonist and an agonist antibody against OX40 could help treat lymphoma, breast cancer and colorectal cancer. In a mouse model of...
8:25 AM, Feb 07, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Melanoma Cell culture and mouse studies suggest a soluble form of SLAMF6 could enhance the effectiveness of T cell therapies for melanoma. In cultures of activated and expanded human tumor-infiltrating lymphocytes and mouse lymphocytes, a...
11:10 AM, Feb 06, 2018  |  BC Innovations | Strategy

#NoneOfYourBusiness

In an era of heightened concerns about the politicization of science, it would be logical to expect peer-reviewed journals, the beating heart of the scientific enterprise, to recognize the need to shield science and scientists...

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