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    E.g., 2018-07-15

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14318 items
1:50 PM, Jun 28, 2018  |  BC Innovations | Translation in Brief

Against the gradient

In a paper published in Nature Communications, University of Copenhagen researchers identified solute carrier family 12 potassium-chloride transporter member 2 (SLC12A2; NKCC1) as one protein by which CSF is transported into the brain, introducing a...
12:52 PM, Jun 28, 2018  |  BC Innovations | Emerging Company Profile

Stress relief for neurons

Aquinnah Pharmaceuticals is developing disease-modifying therapies for amyotrophic lateral sclerosis and Alzheimer’s disease by inhibiting the formation of stress granules that promote protein aggregation in neurons. Stress granules are protein-RNA complexes assembled by RNA-binding proteins that...
11:25 AM, Jun 28, 2018  |  BC Innovations | Translation in Brief

Synchronous signaling

As researchers explore next-generation CARs in cancer, one strategy is to tinker with the receptors’ modular components. A Science Signaling paper suggests that altering the number of ITAM repeats in the intracellular domains of a...
10:54 AM, Jun 28, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Breast cancer In vitro, cell culture and mouse studies identified two benzenesulfonamide-based AXL inhibitors that could help treat breast cancer. Chemical synthesis and in vitro enzymatic activity assays of benzenesulfonamide analogs yielded two compounds that...
10:53 AM, Jun 28, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Cancer; gastric cancer; lung cancer; brain cancer In vitro, cell culture and mouse studies identified four methylquinazoline-based PI3K inhibitors that could help treat cancer. Chemical synthesis of methylquinazoline analogs and in vitro enzyme activity assays...
10:52 AM, Jun 28, 2018  |  BC Innovations | Distillery Therapeutics

Neurology

INDICATION: Addiction Rat studies suggest agonizing GPR139 could help treat alcohol addiction. In a rat model of alcohol dependence, oral administration or intracerebral injection into the habenula of a tool compound GPR139 agonist decreased alcohol intake...
10:52 AM, Jun 28, 2018  |  BC Innovations | Distillery Therapeutics

Autoimmune disease; transplant; endocrine/metabolic

INDICATION: Multiple sclerosis (MS); graft-versus-host disease (GvHD); diabetes Cell culture and mouse studies suggest that IL-2 complexed with an anti-IL-2 mAb could help treat GvHD, MS, Type I diabetes and other autoimmune diseases. In human peripheral...
10:52 AM, Jun 28, 2018  |  BC Innovations | Distillery Therapeutics

Infectious disease

INDICATION: Staphylococcus; Streptococcus Cell culture studies identified a novel class of antimicrobial peptides that could help treat methicillin-resistant Staphylococcus aureus (MRSA) and Streptococcus pneumoniae infections. Testing of extracts of Microbacterium arborescens in bacterial cultures yielded multiple...
10:52 AM, Jun 28, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Brain cancer Mouse studies suggest transferrin-conjugated liposomal nanoparticles loaded with temozolomide and an inhibitor of BET bromodomain proteins could help treat glioma. The liposomal nanoparticles contain distearoylglycerophosphoethanolamine (DSPE) conjugated to polyethylene glycol (PEG) and...
10:50 AM, Jun 28, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Melanoma Patient sample, cell culture and mouse studies suggest inhibiting ELP3 or CTU2 could help treat drug-resistant BRAF-mutant melanoma. In tumor samples from melanoma patients, high expression of genes regulating post-transcriptional tRNA modification, including ELP3...

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