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    E.g., 2018-11-17

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2:11 PM, Nov 07, 2018  |  BC Innovations | Translation in Brief

M is for Chemoproteomic Momentum

An October Nature paper from a University of Cambridge team is the second in as many years to highlight the utility of functionalizing methionine, an amino acid that has garnered less attention than others in...
11:29 AM, Nov 07, 2018  |  BC Innovations | Translation in Brief

Expanding the reach of plant exosomes

A University of Louisville team has shown how plant-derived exosomes could mobilize the gut microbiome against colitis, broadening the range of potential indications for the technology beyond those the university already has in Phase I...
12:48 PM, Nov 06, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Brain cancer Patient sample, cell culture and mouse studies suggest inhibiting PRMT2 could help treat glioblastoma multiforme (GBM). In GBM patients, high tumor levels of PRMT2 were associated with poor survival. In two human GBM...
12:48 PM, Nov 06, 2018  |  BC Innovations | Distillery Therapeutics

Infectious disease

INDICATION: Respiratory syncytial virus (RSV) Cell culture, mouse and rat studies identified an RSV F protein inhibitor that could help treat RSV infection. Optimization and testing in HeLa cell-based assays of a previously reported quinoline-based compound...
12:47 PM, Nov 06, 2018  |  BC Innovations | Distillery Therapeutics

Infectious disease

INDICATION: Influenza virus Cell culture and mouse studies suggest a quadspecific antibody against influenza A and influenza B HA epitopes could help prevent infection by multiple strains of influenza A and influenza B viruses. The...
12:46 PM, Nov 06, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Renal cancer Patient sample and mouse studies suggest promoting expression of IRF9 and STAT2 could help treat clear cell renal cell carcinoma (ccRCC). In patients, low levels of IRF9 in tumor samples were associated with...
12:46 PM, Nov 06, 2018  |  BC Innovations | Distillery Therapeutics

Neurology

INDICATION: Parkinson’s disease Patient sample, mouse and rat studies identified an NLRP3 inhibitor that could help treat PD. In patient postmortem brain tissue samples, levels of NLRP3 in the substantia nigra were higher than in...
12:46 PM, Nov 06, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Liver cancer In silico, in vitro, cell culture and mouse studies identified a positive allosteric modulator (PAM) of SIRT6 that could help treat hepatocellular carcinoma (HCC). In silico screening of a small molecule library for...
12:45 PM, Nov 06, 2018  |  BC Innovations | Distillery Therapeutics

Infectious disease

INDICATION: Clostridium Cell culture studies suggest the tryptophan analogs 1-acetyl-β-carboline and turbomycin A could help treat Clostridium difficile infection (CDI). In C. difficile culture, the bacterial and fungal metabolite 1-acetyl-β-carboline and the antibiotic turbomycin A inhibited...
12:45 PM, Nov 06, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Colorectal cancer, pancreatic cancer Patient sample and mouse studies suggest combining DNA-PK inhibitors with the oncolytic alphavirus M1 could help treat colorectal and pancreatic cancers. In colorectal tumor cells from patients, a DNA-PK inhibitor...

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