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14260 items
12:04 PM, Jun 20, 2018  |  BC Innovations | Distillery Therapeutics


INDICATION: Hematology Patient sample and mouse studies suggest gene editing of CD40L cDNA in autologous hematopoietic stem cells (HSCs) could help treat X-linked hyper-IgM syndrome (XHIM), which is caused by CD40L mutations. In patient-derived T cells,...
4:55 PM, Jun 14, 2018  |  BC Innovations | Strategy

Meta on data

NIH is grasping the nettle and turning its attention to solving the big practical questions about big data. Stopping short of a vision for how data science should drive discovery, NIH has laid out a...
4:27 PM, Jun 14, 2018  |  BC Innovations | Tools & Techniques

Imaging immunotherapy

Stanford University researchers have made an imaging agent that detects activated T cells and could predict whether a patient will respond to immunotherapy within days of treatment. Typically, it takes weeks to months to determine...
3:06 PM, Jun 14, 2018  |  BC Innovations | Translation in Brief

There’s more to MIF

In a May Science Translational Medicine study, a European-U.S. team has shown macrophage migration inhibitory factor or sCD74, a soluble form of one its receptors, could reduce the risk of acute kidney injury in cardiac...
2:50 PM, Jun 14, 2018  |  BC Innovations | Emerging Company Profile

Beaming about base changes

Beam Therapeutics launched with a CRISPR-guided base editor platform that could introduce more precise point mutations than other gene editing technologies without the risk of off-target cuts. Founded by CRISPR veterans David Liu of Harvard University,...
2:13 PM, Jun 13, 2018  |  BC Innovations | Translation in Brief

Quorum sensitivity

By engineering HEK cells with machinery to produce and secrete quorum-sensing molecules, an ETH Zurich team has developed microbe-sensing technology it believes could prevent the development of drug resistance by reducing biofilm formation and possibly...
11:26 AM, Jun 13, 2018  |  BC Innovations | Distillery Techniques


TECHNOLOGY: Computational models A method for designing small molecules that bind two protein targets could be used to generate dual inhibitors. The method utilizes in silico docking of a library of drug-like compounds and compound fragments...
11:26 AM, Jun 13, 2018  |  BC Innovations | Distillery Techniques

Assays and screens

TECHNOLOGY: Diagnostic assays A microfluidics-based method for detecting tumor cells in urine could help diagnose bladder cancer. The assay involves two steps: adding patient urine samples to a microfluidics device consisting of a chamber for directional...
11:25 AM, Jun 13, 2018  |  BC Innovations | Distillery Techniques

Disease models

TECHNOLOGY: Transgenics and knockouts Mice expressing a COL17A1 variant could be used to screen therapies for inflammatory skin diseases. Mice with skin-specific knock-in of a COL17A1 variant lacking the NC16A domain recapitulated the skin inflammation, eczematous...
11:25 AM, Jun 13, 2018  |  BC Innovations | Distillery Techniques

Drug delivery

TECHNOLOGY: Other Exosomes could be used to deliver peptide-conjugated nucleic acid therapies for multiple diseases. The method involves loading exosomes with therapeutic nucleic acids conjugated to a 12-amino acid peptide engineered to bind the extracellular domain...