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14756 items
10:47 AM, Nov 13, 2018  |  BC Innovations | Distillery Techniques

Assays and screens

TECHNOLOGY: Cell-free assay; diagnostic assays A nanopore-based system for quantifying metabolites in bodily fluids could be used to develop point-of-care diagnostics for multiple diseases, including stroke, Parkinson’s disease (PD) and insulin resistance. The method involves...
3:22 PM, Nov 12, 2018  |  BC Innovations | Translation in Brief

Circulating DNA: what counts in the end

A Chinese University of Hong Kong team co-led by Dennis Lo has taken circulating cell-free DNA (cfDNA) in a new direction by measuring a ratio based on counts of cfDNA fragments, rather than sequencing the...
3:56 PM, Nov 09, 2018  |  BC Innovations | Distillery Therapeutics


INDICATION: Diabetes; obesity Patient sample, cell culture and mouse studies suggest inhibiting FXR with glycoursodeoxycholic acid could help treat obesity and obesity-related diabetes. In Type II diabetes patients receiving the generic diabetes drug metformin, serum and...
3:56 PM, Nov 09, 2018  |  BC Innovations | Distillery Therapeutics


INDICATION: Colitis Mouse studies suggest exosome-like nanoparticles (ELNs) from the ginger plant or ginger-based nanovesicles loaded with ELN microRNA (miRNA) could help treat colitis. In a mouse model of colitis, ELNs derived from ginger or artificial...
1:20 PM, Nov 09, 2018  |  BC Innovations | Distillery Therapeutics


INDICATION: Colorectal cancer; cancer In vitro, cell culture and mouse studies identified a CDK9 inhibitor that could help treat colorectal and other cancers. Screening of a natural product library followed by chemical synthesis and in vitro...
11:07 AM, Nov 09, 2018  |  BC Innovations | Distillery Techniques

Chemistry; drug platforms

TECHNOLOGY: Synthetic chemistry; conjugates A method for linking methionine residues to small molecules could be used to generate novel therapeutic protein-drug conjugates. The method involves two steps: adding a diazo-iodonium salt to a protein or peptide...
8:47 PM, Nov 08, 2018  |  BC Innovations | Tools & Techniques

HitGen’s DNA for small molecules

With more than 60 partnerships under its belt, HitGen Ltd. has become a major gateway for companies to access DNA-encoded library technology -- a high efficiency form of combinatorial chemistry that upstages high throughput screening....
2:41 PM, Nov 08, 2018  |  BC Innovations | Product R&D

JLABS seeks lung cancer solutions in Shanghai

As Johnson & Johnson gears up to launch its Shanghai JLABS site early next year, the incubator’s head, Sharon Chan, has pegged lung cancer as one of the first priorities. Chan sees opportunity in China...
11:55 AM, Nov 08, 2018  |  BC Innovations | Emerging Company Profile

Abarceo: restoring beta cell function

Abarceo Pharma AB has identified VDAC1 as a key target in Type II diabetes, and is developing antibodies and small molecule inhibitors against the target as durable and disease-modifying treatments. Standard first-line therapy for Type II...
7:29 AM, Nov 08, 2018  |  BC Innovations | Translation in Brief

Solid plans for CDK9

A team led by Temple University scientists has shed light on a new epigenetic mechanism behind a known cancer target, cyclin dependent kinase 9 (CDK9), that may broaden the scope of CDK9 inhibitors to include...