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14161 items
11:19 AM, May 23, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Lung Cancer Patient sample, cell culture and mouse studies suggest promoting expression of the long non-coding RNA (lncRNA) LINC00472 could help treat lung cancer. In patient samples, levels of LINC00472 were higher in tumors than...
9:20 AM, May 23, 2018  |  BC Innovations | Distillery Techniques

Biomarkers

TECHNOLOGY: Tissue markers Tumor clone frequencies of TCRB in lesional skin could help predict survival and progression in mycosis fungoides, a subtype of cutaneous T cell lymphoma (CTCL). TCRB tumor clone frequency is calculated by sequencing...
9:20 AM, May 23, 2018  |  BC Innovations | Distillery Techniques

Disease models

TECHNOLOGY: Animal models Mice treated prenatally with AMH could be used to screen therapies to treat polycystic ovary syndrome, a partially heritable disease. In blood samples from 66 pregnant patients with PCOS, AMH levels were higher...
9:20 AM, May 23, 2018  |  BC Innovations | Distillery Techniques

Assays and screens; biomarkers

TECHNOLOGY: Cell-free assays; gene profiling A method for profiling miRNAs in extracellular vesicles could be used to identify diagnostic markers for pancreatic and other cancers. The method involves linking magnetic anti-biotin microbeads to biotinylated antibodies that...
9:19 AM, May 23, 2018  |  BC Innovations | Distillery Techniques

Biomarkers

TECHNOLOGY: Plasma markers Plasma levels of unmethylated RFLNA cfDNA could help diagnose MI or sepsis. In 70 patients with acute MI and 201 patients with sepsis, levels of unmethylated RFLNA cfDNA were higher than in 83...
9:19 AM, May 23, 2018  |  BC Innovations | Distillery Techniques

Drug platforms

TECHNOLOGY: Structural analyses Structural analyses of NPY1R bound to tool compound antagonists or its endogenous agonist NPY could guide the design of compounds that antagonize or agonize the receptor for obesity, cancer or bone loss....
1:38 PM, May 17, 2018  |  BC Innovations | Emerging Company Profile

Beyond B cells

PureTech Health plc subsidiary Vor Biopharma Inc. plans to combine CAR T therapies with hematopoietic stem cells modified to go unrecognized by CAR Ts. The approach could increase the types of immune cells that can...
12:34 PM, May 17, 2018  |  BC Innovations | Finance

Europe’s piece of the pie

With China’s rising infrastructure for life science innovation and the unabated growth of U.S. science, Europe has two cards to play that can help it compete globally: expertise in key core technologies and its centralized...
11:51 AM, May 17, 2018  |  BC Innovations | Translation in Brief

A LRRK-ing link

In a pair of studies, researchers from Icahn School of Medicine at Mount Sinai identified links between Parkinson’s disease and inflammatory bowel disease that could spur the development of existing therapies for new indications. In...
10:56 AM, May 16, 2018  |  BC Innovations | Distillery Therapeutics

Neurology

INDICATION: Rett syndrome Patient sample and mouse studies suggest inhibiting GSK3B could help treat Rett syndrome. In postmortem cerebellum tissue samples from Rett syndrome patients, levels of GSK3B were higher than in samples from unaffected subjects....

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