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14549 items
9:43 AM, Sep 19, 2018  |  BC Innovations | Distillery Techniques

Biomarkers

TECHNOLOGY: Gene profiling; tissue markers Tumor levels of a nine-gene signature could help predict survival in TNBC. In 868 epithelial cells from tumor samples from six patients with primary non-metastatic TNBC, single-cell RNA sequencing, gene expression...
9:42 AM, Sep 19, 2018  |  BC Innovations | Distillery Techniques

Drug platforms

TECHNOLOGY: Cell therapy A method for differentiating HSPCs into megakaryocytes by overexpressing or activating one of 15 genes could help generate platelet-producing megakaryocyte colonies for thrombocytopenia. The method involves two steps: generating megakaryocyte progenitor cells by...
9:42 AM, Sep 19, 2018  |  BC Innovations | Distillery Techniques

Assays and screens; biomarkers; other

TECHNOLOGY: Bioinformatics; gene profiling; computational models Computational models based on tumor levels of lncRNAs could help predict resistance to cancer therapies. The method involves a machine learning algorithm that uses the expression levels of 2,614...
9:42 AM, Sep 19, 2018  |  BC Innovations | Distillery Techniques

Chemistry

TECHNOLOGY: Tool compounds A heterocycloalkynylbenzimide-based dual DDR1/DDR2 inhibitor could be used to probe the role of two proteins in inflammatory diseases. Chemical synthesis and in vitro activity assays of heterocycloalkynylbenzimide analogs identified a compound that...
2:43 PM, Sep 18, 2018  |  BC Innovations | Translation in Brief

Advanced drivers’ ed for cancer

A pair of studies published this month in Science and Nature could help inform cancer treatment decisions by providing a more nuanced portrait of driver gene mutation heterogeneity between metastatic tumors and between discrete precancerous...
7:37 PM, Sep 13, 2018  |  BC Innovations | Product R&D

Academia’s manufacturing problem

With backups at academic manufacturing centers beginning to hamper translation of early stage gene therapies, pushing those who can afford it to CMOs, at least one non-profit has stepped in with a model to deliver...
6:50 PM, Sep 13, 2018  |  BC Innovations | Targets & Mechanisms

Repeat offenders

Dozens of intractable DNA repeat-driven diseases could boil down to a common problem: disrupted boundaries between chromatin domains, according to a study from the University of Pennsylvania. The results present new opportunities for diseases like...
3:07 PM, Sep 13, 2018  |  BC Innovations | Translation in Brief

New Therapeutic Targets and Biomarkers: August 2018

New Therapeutic Targets and Biomarkers: August 2018 Select top therapeutic targets and biomarkers covered by BioCentury or added to the BCIQ database in August 2018. Therapeutic targets are defined as any protein, gene or other molecule...
1:42 PM, Sep 13, 2018  |  BC Innovations | Emerging Company Profile

Mapping tumor markers

BioGraph 55 Inc. is mapping immune cells in the tumor microenvironment to identify cell-to-cell interaction patterns that can help match patients to existing therapies and identify novel therapeutic targets. The newco is developing a pipeline...
11:34 AM, Sep 13, 2018  |  BC Innovations | Translation in Brief

Propagating Parkinson’s along the gut-brain axis

George Tetz and colleagues from the Human Microbiology Institute have found bacteriophages in the gut microbiome that they think contribute to Parkinson’s disease by traveling up the gut-brain axis. The gut-brain axis is a network of...

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