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    E.g., 2018-02-20

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13798 items
4:55 PM, Feb 13, 2018  |  BC Innovations | Distillery Therapeutics

Infectious disease

INDICATION: HIV / AIDS Mouse studies identified a prodrug of the HIV integrase inhibitor Tivicay dolutegravir that could help treat HIV infection. The prodrug consists of Tivicay modified with myristic acid for formation of hydrophobic and...
4:55 PM, Feb 13, 2018  |  BC Innovations | Distillery Therapeutics

Cardiovascular

INDICATION: Aneurysm Mouse studies suggest the CysLT1 inhibitor Singulair montelukast could help treat abdominal aortic aneurysm (AAA). In a mouse model of calcium chloride-induced AAA, Singulair decreased aortic dilation compared with no treatment. In a...
8:59 AM, Feb 13, 2018  |  BC Innovations | Distillery Techniques

Assays and screens

TECHNOLOGY: Binding assays A method for unbiased detection of protein-small molecule interactions could be used to identify the protein targets of small molecules. The method involves four steps: exposing a proteome sample to a metabolite or...
8:58 AM, Feb 13, 2018  |  BC Innovations | Distillery Techniques

Other

TECHNOLOGY: Computational models A method for designing small molecules that covalently bind conserved catalytic lysines could be used to generate selective, irreversible kinase inhibitors. The method utilizes in silico modeling of the interactions between analogs of...
8:58 AM, Feb 13, 2018  |  BC Innovations | Distillery Techniques

Chemistry

TECHNOLOGY: Tool compounds A diazepine-based compound could be used to probe the role of SPPL2A in antigen-presenting cells (APCs) that drive rheumatoid arthritis, multiple sclerosis and other autoimmune diseases. Chemical synthesis, in vitro testing and cell-based...
8:58 AM, Feb 13, 2018  |  BC Innovations | Distillery Techniques

Assays and screens; disease models

TECHNOLOGY: Cellular assays; 3-D models A 3-D culture system that mimics brain tissue could be used to model drug resistance in glioblastoma multiforme and screen therapies. The system involves culturing human GBM cell lines in a...
8:57 AM, Feb 13, 2018  |  BC Innovations | Distillery Techniques

Biomarkers

TECHNOLOGY: SNPs A SNP on PAD4 could help predict the risk of ALS. Genome-wide association studies in 1,955 ALS patients and 28,244 unaffected individuals identified an associations between a SNP on PAD4, SNP (rs2240335), and ALS,...
8:56 AM, Feb 13, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Ovarian cancer Cell culture and mouse studies suggest inhibiting MENA could help treat metastases of serous ovarian cancer. In a panel of serous ovarian cancer cell lines, expression of the MENA isoform MENAΔv6 was associated...
8:54 AM, Feb 13, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Breast cancer Patient sample, cell culture and mouse studies suggest inhibiting CHORDC1 could help treat metastatic breast cancer. In patients, high levels of CHORDC1 in primary tumors were associated with tumor invasiveness and poor overall...
8:53 AM, Feb 13, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Bone cancer Patient sample and mouse studies suggest inhibiting tissue factor could help treat metastatic osteosarcoma. In patient tumor samples, levels of histone H3 methylation at an enhancer sequence upstream of the TF gene --...

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