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    E.g., 2018-06-27

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14161 items
11:24 AM, May 23, 2018  |  BC Innovations | Distillery Therapeutics

Neurology

INDICATION: Alzheimer’s disease (AD) Patient sample and mouse studies suggest inhibiting P2RY1 or ITPR2 could help treat AD. In brain samples from patients, levels of P2RY1 were higher in cortical astrocytes surrounding β-amyloid plaques than in...
11:24 AM, May 23, 2018  |  BC Innovations | Distillery Therapeutics

Autoimmune disease

INDICATION: Arthritis Patient sample and mouse studies suggest inhibiting NOS2 could help treat psoriatic arthritis. In peripheral blood mononuclear cells (PBMCs) from patients, levels of NOS2 were higher than in healthy volunteers. In a mouse model...
11:23 AM, May 23, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Breast cancer; brain cancer; solid tumors Mouse studies suggest liposomal nanoparticles loaded with immunomodulatory agents could enhance the efficacy of CAR T therapies to treat solid cancers. The liposomal nanoparticles are coated with an integrin...
11:22 AM, May 23, 2018  |  BC Innovations | Distillery Therapeutics

Neurology

INDICATION: Nerve damage Mouse studies suggest agonizing ESR2 could help treat enteric nerve damage. In a mouse model of chemical-induced damage to the ileal myenteric plexus, a subcutaneous ESR2 agonist tool compound decreased the neuron-depleted area...
11:22 AM, May 23, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Prostate cancer Patient sample, cell culture and mouse studies suggest inhibiting β-catenin in combination with Xtandi enzalutamide could help treat prostate cancer. In tumor samples from prostate cancer patients, levels of β-catenin were higher in...
11:21 AM, May 23, 2018  |  BC Innovations | Distillery Therapeutics

Neurology; musculoskeletal

INDICATION: Amyotrophic lateral sclerosis (ALS); musculoskeletal In vitro, cell culture and fruit fly studies suggest promoting the expression of TNPO1 could help treat ALS caused by FUS mutations and multisystem proteinopathy caused by HNRNPA1 mutations. In...
11:21 AM, May 23, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Colorectal cancer Patient sam/ple and cell culture studies suggest inhibiting DEPTOR could help treat colorectal cancer. In samples of colorectal tumors and the surrounding mucosa from patients, DEPTOR expression was higher than in normal colon...
11:19 AM, May 23, 2018  |  BC Innovations | Distillery Therapeutics

Transplant

INDICATION: Graft-versus-host disease (GvHD) Mouse studies suggest inhibiting DOT1L or overexpressing DUSP6 could help treat GvHD associated with T cell therapies. In a mouse model of xenogeneic T cell-associated GvHD, adoptive transfer of human CD8+...
11:19 AM, May 23, 2018  |  BC Innovations | Distillery Therapeutics

Infectious disease

INDICATION: HIV/AIDS Patient sample and cell culture studies identified three broadly neutralizing antibodies (bNAbs) against HIV gp120 that could help treat the infection. Screening of neutralizing antibodies against HIV gp120 isolated from a patient with natural...
11:19 AM, May 23, 2018  |  BC Innovations | Distillery Therapeutics

Neurology

INDICATION: Alzheimer’s disease (AD) Patient sample, cell culture and mouse studies suggest promoting SPHK1 expression could help treat AD. In postmortem brain tissue samples from AD patients, neuron levels of SPHK1 were lower than in...

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