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14549 items
8:19 AM, Sep 20, 2018  |  BC Innovations | Distillery Therapeutics

Infectious disease

INDICATION: Influenza virus Cell culture and mouse studies suggest inhibiting GRK2 could help treat influenza A infection. In a human alveolar basal epithelium cell line infected with human or avian strains of influenza A, an siRNA...
8:19 AM, Sep 20, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Gastrointestinal cancer Cell culture and mouse studies identified a quinazoline-based compound that could help treat c-Kit- and PDGFR-mutant gastrointestinal stromal tumors (GISTs). Chemical synthesis of phenoxyquinazoline- and quinolone-based PDGFRA inhibitors followed by testing in mouse...
8:19 AM, Sep 20, 2018  |  BC Innovations | Distillery Therapeutics

Neurology; ophthalmic disease

INDICATION: Parkinson’s disease (PD); neurology; blindness Fruit fly studies suggest inhibiting ITPR, VDAC1, MCU, MIRO1 and/or MIRO2 could help treat PD, other neurodegenerative diseases and blindness. In a Drosophila model of PD, knockdown of ITPR or...
8:18 AM, Sep 20, 2018  |  BC Innovations | Distillery Therapeutics

Autoimmune disease

INDICATION: Multiple sclerosis (MS) Mouse studies suggest ablating meningeal lymphatic vessels with Visudyne verteporfin could help treat MS. In the experimental autoimmune encephalomyelitis (EAE) mouse model of MS, injection into the cisterna magna of Visudyne followed...
8:18 AM, Sep 20, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Brain cancer Cell culture and mouse studies suggest inhibiting GLS could enhance the efficacy of radiation or reactive oxygen species (ROS)-inducing drugs in IDH1-mutant glioma. In a human glioma cell line expressing mutant IDH1, the...
8:18 AM, Sep 20, 2018  |  BC Innovations | Distillery Therapeutics

Infectious disease

INDICATION: Gram-negative bacterial infection Mouse studies identified a member of the arylomycin class of bacterial lepB-inhibiting antibiotics that could help treat multidrug resistant (MDR) Gram-negative bacterial infections. Chemical synthesis and in vitro assays of arylomycin...
8:17 AM, Sep 20, 2018  |  BC Innovations | Distillery Therapeutics

Otologic

INDICATION: Hearing loss Mouse studies suggest inhibiting DDIT3 or PERK could help treat hearing loss. In a mouse model of genetic hearing loss, systemic knockout of DDIT3 decreased hearing loss compared with normal DDIT3 expression. In...
2:32 PM, Sep 19, 2018  |  BC Innovations | Translation in Brief

To eat and not to eat

A Nature Communications paper published last month by Forty Seven Inc. (NASDAQ:FTSV) co-founder Irving Weissman and colleagues at Stanford University highlights a new strategy for boosting “eat me” signals on cancer cells that could complement...
9:44 AM, Sep 19, 2018  |  BC Innovations | Distillery Techniques

Biomarkers

TECHNOLOGY: SNPs SNPs on PKN1, DOK2 and APOB could help predict the risk of pancreatic ductal adenocarcinoma (PDAC) in the Chinese population. In 943 PDAC patients and 3,908 healthy volunteers of Chinese descent, whole-exome screening identified...
9:44 AM, Sep 19, 2018  |  BC Innovations | Distillery Techniques

Drug delivery

TECHNOLOGY: Other Degradable aminoester cations could be used to deliver mRNA-based cancer vaccines. The delivery system involves complexing both an antigen-coding mRNA and an adjuvant with oligo(α-aminoester) cations that are endocytosed by any cell and degrade...

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