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    E.g., 2018-07-15

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14318 items
2:44 PM, Jul 10, 2018  |  BC Innovations | Distillery Techniques

Biomarkers; other

TECHNOLOGY: Tissue markers; metabolomics; plasma markers; computational models Computational models based on profiles of the fecal metagenome, plasma and urine metabolites and the liver transcriptome could help diagnose hepatic steatosis in non-diabetic obese women. In 158...
2:41 PM, Jul 10, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Head and neck cancer Cell culture and mouse studies suggest BRD4 inhibitors could help treat cetuximab-resistant squamous cell carcinoma of the head and neck (SCCHN). In two human cetuximab-resistant SCCHN cell lines, cetuximab plus...
2:41 PM, Jul 10, 2018  |  BC Innovations | Distillery Therapeutics

Neurology

INDICATION: Pain Mouse studies suggest inhibiting DLK could help treat neuropathic pain associated with peripheral nerve injury. In two mouse models of peripheral nerve injury-induced neuropathic pain, systemic knockout of DLK or a tool compound DLK...
2:41 PM, Jul 10, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Colorectal cancer; breast cancer Patient sample and mouse studies suggest inhibiting CNR2 or promoting MGLL expression could help treat colorectal and breast cancers. In tumor samples from 30 colorectal cancer patients, levels of CNR2 were...
2:40 PM, Jul 10, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Sarcoma Cell culture and mouse studies suggest combining Mekinist trametinib with IGF1R inhibitors could help treat PAX3-PAX7 fusion-negative rhabdomyosarcoma. Screening of a panel of 1,912 approved or tool compound small molecule inhibitors in a viability...
2:39 PM, Jul 10, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Liver cancer In vitro, cell culture and mouse studies identified a SALL4-derived peptide inhibitor of the SALL4-RBBP4 interaction that could help treat hepatocellular carcinoma (HCC). Chemical synthesis and in vitro testing of analogs of a...
2:39 PM, Jul 10, 2018  |  BC Innovations | Distillery Therapeutics

Neurology

INDICATION: Pain Cell culture and mouse studies identified a TRPM8 antagonist that could help treat pain. Chemical synthesis of dibenzyl tryptamine analogs and HEK cell-based ion channel assays yielded a compound that inhibited TRPM8 with an...
2:38 PM, Jul 10, 2018  |  BC Innovations | Distillery Therapeutics

Cancer; infectious disease

INDICATION: Acute myelogenous leukemia (AML); Candida In vitro, cell culture and mouse studies identified an aminopyrimidine-based dual JAK-2/HDAC6 inhibitor that could help treat AML and Candida albicans infection. Chemical synthesis of aminopyrimidine analogs linked to hydroxamic...
2:38 PM, Jul 10, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Small cell lung cancer Patient sample and cell culture studies suggest promoting IGFBP5 expression or inhibiting POU2F3 or IGF1R could help treat POU2F3-expressing small cell lung cancer (SCLC). In tumor samples from SCLC patients,...
2:37 PM, Jul 10, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Breast cancer Cell culture studies suggest promoting interactions between miR-34a and tRNA-iMet could help treat breast cancer. In a panel of human breast cancer cell lines, levels of miR-34a were lower and levels of its...

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