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    E.g., 2018-11-15

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14752 items
10:49 AM, Nov 13, 2018  |  BC Innovations | Distillery Therapeutics

Ophthalmic disease

INDICATION: Blindness Mouse studies suggest inhibiting ATXN7 could help treat vision loss in spinocerebellar ataxia type 7 (SCA7), which is caused by gain-of-function mutations in the gene. In a genetic mouse model of SCA7, intravitreal injection...
10:48 AM, Nov 13, 2018  |  BC Innovations | Distillery Therapeutics

Hepatic

INDICATION: Liver fibrosis Patient sample and mouse studies suggest antagonizing AHR or RORγT could help treat liver fibrosis. In liver tissue samples from hepatitis patients, levels of IL-17A and IL-22, which are positively regulated by AHR...
10:47 AM, Nov 13, 2018  |  BC Innovations | Distillery Techniques

Disease models

TECHNOLOGY: Transgenics and knockouts miR-137-deficient mice could be used to screen therapies for schizophrenia, autism and other neuropsychiatric disorders. Mice with miR-137 knocked out in CNS and peripheral nervous system neurons recapitulated the learning and memory...
10:47 AM, Nov 13, 2018  |  BC Innovations | Distillery Techniques

Biomarkers

TECHNOLOGY: Plasma markers A ratio based on counts of fragmentation sites in plasma cfDNA could help diagnose HCC. In a patient with both HCC and HBV infection and a patient with HBV infection, genomic sequencing...
10:47 AM, Nov 13, 2018  |  BC Innovations | Distillery Techniques

Disease models

TECHNOLOGY: Cell models Gene expression profiles in neural progenitor cells derived from patients' iPS cells could be used to screen therapies for schizophrenia. The method involves generating neural progenitor cell lines from iPS cells derived from...
10:47 AM, Nov 13, 2018  |  BC Innovations | Distillery Techniques

Imaging

TECHNOLOGY: MRI A machine learning-based method of analyzing neuroimaging MRI data could help diagnose subtypes and stages of neurodegenerative diseases. For each neurodegenerative disease, the method involves: determining the number of subtypes from a training set...
10:47 AM, Nov 13, 2018  |  BC Innovations | Distillery Techniques

Assays and screens

TECHNOLOGY: Cell-free assay; diagnostic assays A nanopore-based system for quantifying metabolites in bodily fluids could be used to develop point-of-care diagnostics for multiple diseases, including stroke, Parkinson’s disease (PD) and insulin resistance. The method involves...
3:22 PM, Nov 12, 2018  |  BC Innovations | Translation in Brief

Circulating DNA: what counts in the end

A Chinese University of Hong Kong team co-led by Dennis Lo has taken circulating cell-free DNA (cfDNA) in a new direction by measuring a ratio based on counts of cfDNA fragments, rather than sequencing the...
3:56 PM, Nov 09, 2018  |  BC Innovations | Distillery Therapeutics

Endocrine/Metabolic

INDICATION: Diabetes; obesity Patient sample, cell culture and mouse studies suggest inhibiting FXR with glycoursodeoxycholic acid could help treat obesity and obesity-related diabetes. In Type II diabetes patients receiving the generic diabetes drug metformin, serum and...
3:56 PM, Nov 09, 2018  |  BC Innovations | Distillery Therapeutics

Gastrointestinal

INDICATION: Colitis Mouse studies suggest exosome-like nanoparticles (ELNs) from the ginger plant or ginger-based nanovesicles loaded with ELN microRNA (miRNA) could help treat colitis. In a mouse model of colitis, ELNs derived from ginger or artificial...

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