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14344 items
3:19 PM, Jul 19, 2018  |  BC Innovations | Translation in Brief

Public Funding Highlights: 2Q18

Public Funding Highlights: 2Q18 Selected developments and initiatives in 2Q18 from major sources of public funding including National Institutes of Health (NIH), the U.K.’s Medical Research Council (MRC), the Innovative Medicines Initiative (IMI) and the Canadian...
3:04 PM, Jul 19, 2018  |  BC Innovations | Tools & Techniques

Immunotherapy Matchmaking

MD Anderson Cancer Center is using its access to patient samples to inject more rationality into decisions about which therapies should be paired with checkpoint inhibitors, and how to optimize the combos. The goal is...
8:21 AM, Jul 19, 2018  |  BC Innovations | Translation in Brief

Inflammatory images

A University of Calgary team has implicated the inflammasome in acute kidney injury induced by contrast imaging agents and identified targets that could help prevent it. In patients with diminished renal function, such as those with...
1:26 PM, Jul 18, 2018  |  BC Innovations | Emerging Company Profile

Ministring theory in practice

Mediphage Bioceuticals Inc.’s ministrings have safety, manufacturing and other advantages that could give conventional plasmids and related vectors a run for their money in the gene therapy space. The newco’s ministrings are linear DNAs with covalently...
10:04 AM, Jul 18, 2018  |  BC Innovations | Translation in Brief

Playing chicken with metastasis

In a June study published in Nature Communications, a University of Alberta team described an in vivo screen that identified genetic drivers of cancer metastasis, and the university has spun out Entos Pharmaceuticals Inc. to...
8:41 AM, Jul 18, 2018  |  BC Innovations | Distillery Techniques

Drug platforms

TECHNOLOGY: Cell therapy A non-viral CRISPR-Cas9-based method for engineering patient-derived T cells could be used to generate personalized cell therapies for cancer and autoimmune diseases. The method consists of co-electroporating T cells collected from the...
8:41 AM, Jul 18, 2018  |  BC Innovations | Distillery Techniques


TECHNOLOGY: Gene profiling Mutations in hematopoiesis-associated genes could help predict the risk of AML. Genomic sequencing of 124 patients who later developed AML and 686 healthy volunteers identified associations between the disease and mutations in 22...
8:41 AM, Jul 18, 2018  |  BC Innovations | Distillery Techniques

Assays and screens

TECHNOLOGY: Cellular assays A chicken embryo-based method of screening genes required for tumor cell motility could identify new targets for cancer metastasis. The method involves six steps: transducing metastatic cancer cells with a human shRNA library;...
8:41 AM, Jul 18, 2018  |  BC Innovations | Distillery Techniques

Drug platforms

TECHNOLOGY: Peptides A fibrin matrix loaded with synthetic laminin peptides that bind growth factors could be used for wound healing and tissue regeneration applications. The peptides are 24- and 19-mer synthetic analogs of human laminin α...
2:58 PM, Jul 17, 2018  |  BC Innovations | Product R&D

Natural spots

With a new take on allosteric modulation, HotSpot Therapeutics Inc. has emerged from stealth mode to find specialized niches on proteins that nature uses to control their activity. The company’s platform has identified druggable allosteric...