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A telltale mouse to guide AAV design for gene editing

A mouse model puts in vivo AAV activity under the microscope and reveals unexpected opportunities for gene editing

A study from Spark co-founder Beverly Davidson suggests AAV vectors can reach more tissues than previously thought, opening up new opportunities and guidelines for AAV-mediated gene editing.

In a Nature Communications paper, Davidson’s team described a mouse model that reported transient, low levels of AAV transduction with more sensitivity than conventional methods. While such

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